Identification of immune cells involved in chronic graft-versus-host disease and its disease control
Project/Area Number |
24591543
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
|
Research Institution | Kanazawa University |
Principal Investigator |
|
Research Collaborator |
ARAKI Raita
KURODA Rie
MASE Shintaro
MAEBA Hideaki
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 造血幹細胞移植 / 移植片対宿主病 / 肥満細胞 / 慢性GVHD / 骨髄移植 / GVHD |
Outline of Final Research Achievements |
Originally mast cells have been known as effector cells in the IgE-mediated allergic responses. In addition, recent studies demonstrated that mast cells exerted pro-inflammatory or anti-inflammatory effects in complicated immune response depending on the situation. In allogeneic hematopoietic stem cell transplantation (HSCT), exact role of mast cells in graft-versus-host disease (GVHD) remains unclear. Firstly, we have demonstrated that both host-type and donor-type mast cells suppressed mixed lymphocyte reaction in vitro. Secondly, we have shown that absence of both host-typed and donor-typed mast cells exacerbated acute GVHD utilizing mast cell deficient mice. Taken together, mast cells have a protective role against GVHD and cell therapy using cultured mast cell would be promising for refractory GVHD in clinical settings.
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Report
(4 results)
Research Products
(8 results)