| Project/Area Number |
24591573
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya University |
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Principal Investigator |
KATO TAICHI 名古屋大学, 医学部附属病院, 講師 (20422777)
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| Co-Investigator(Kenkyū-buntansha) |
FUKASAWA Yoshie 名古屋大学, 医学部附属病院, 病院助教 (00612764)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Yoshiaki 名古屋大学, 医学部附属病院, 講師 (30435862)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肺高血圧症 / 交感神経 / リモデリング / 肺高血圧 / エンドセリン |
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| Outline of Final Research Achievements |
In this study, the role of perivascular sympathetic nerve in the development of experimental pulmonary arterial hypertension and the effect of endothelin antagonist, ambrisentan, on vascular innervation were investigated. Perivascular sympathetic nerves around pulmonary arteries with the diameter of 50-200μm were very rare. On the other hand, more nerves were confirmed at larger pulmonary arteries. Perivascular sympathetic nerves at larger pulmonary arteries were decreased in pulmonary arterial hypertension group compared to control group. In addition, these distributions were not affected by ambrisentan. These results demonstrated the distribution of perivascular sympathetic nerve in the development of experimental pulmonary arterial hypertension. Furthermore, the effect of ambrisentan on vascular innervation was limited. Therefore, the other factors associated with decreased vascular sympathetic nerve remain to be elucidated.
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