Regulation of skin immunity by regulatory T cell-subset
| Project/Area Number |
24591649
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kyoto University |
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Principal Investigator |
NOMURA Takashi 京都大学, 医学(系)研究科(研究院), その他 (60346054)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 皮膚免疫学 / 免疫制御 / アレルギー / 免疫寛容 / 皮膚免疫 / 制御性T細胞 / 免疫トレランス / Helios |
|---|
| Outline of Final Research Achievements |
Although etiology of atopic dermatitis, psoriasis, and collagen diseases is not fully clarified, it is partly explained by excessively activated immune system. Such over-activation is inhibited by special lymphocytes called regulatory T cells. In this project, we developed Helios-reporter mice, in which Helios-expressing cells expressed fluorescent proteins; and we analyzed live regulatory T cells expressing Helios. Our study revealed that Helios-expressing regulatory T cells possessed a strong suppressive activity. Helios-reporter mice are applicable for developing measures to restrain excessive immune responses or to treat allergic and autoimmune diseases.
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Report
(4 results)
Research Products
(7 results)
