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The effects of glucocorticoid on the expression of caveolin-1 in skin-related cells.

Research Project

Project/Area Number 24591654
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionKagawa University

Principal Investigator

KUBOTA YASUO  香川大学, 医学部, 教授 (10126047)

Co-Investigator(Kenkyū-buntansha) IGARASI Jyunsuke  香川大学, 医学部, 准教授 (20346638)
KOSAKA Hiroaki  香川大学, 医学部, 教授 (60158897)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsカベオリン / 皮膚 / ステロイド / 血管内皮細胞 / VEGF / シグナル伝達 / カベオリン1 / 血管内皮 / カベオラ / 皮膚線維芽細胞 / 表皮角化細胞 / 角化細胞
Outline of Final Research Achievements

We examined the effects of glucocorticoid agents that are frequently used in clinic at dermatology, by using cultured skin-related cells as a model. When vascular endothelial cells derived from humans or cows were treated with glucocorticoids, the expression levels of a key signal regulating molecule termed caveolin-1 were markedly up-regulated at the levels of protein and mRNA. Glucocorticoids were without effect for keratinocytes and fibroblasts, two other major skin component cells. We then explored the effects of glucocorticoids on signaling responses of endothelial cells for stimulation with vascular endothelial growth factor. Markedly attenuated responses were obtained in glucocorticoids-treated cells, which were counteracted by gene knockdown of caveolin-1. Similar observations were obtained in living animals. Thus, our study uncovered previously unidentified effects of glucocorticoids on dermatological cells, in which induction of caveolin-1 plays a key role.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells2014

    • Author(s)
      Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, TakuwaY, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I.
    • Journal Title

      Pharmacology Research & Perspectives

      Volume: 2 Issue: 5 Pages: 68-68

    • DOI

      10.1002/prp2.68

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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