Functional analysis of schizoprenia risk gene, Neurogranin (NRGN)
Project/Area Number |
24591680
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
|
Research Institution | Osaka University |
Principal Investigator |
YASUDA Yuka 大阪大学, 医学部附属病院, 特任助教 (20448062)
|
Co-Investigator(Kenkyū-buntansha) |
YAMAMORI Hidenaga 大阪大学, 医学系研究科, 助教 (90570250)
UMEDA Satomi 大阪大学, 医学系研究科, 研究員 (00625329)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 統合失調症 / ニューログラニン / 遺伝子解析 / 死後脳 / 認知機能 / 知能 / 脳構造画像 / NRGN遺伝子 / GWAS / ゲノム / 神経科学 / 遺伝子発現 / 前部帯状回灰白質体積 / IQ / 遺伝子 / 生物学的精神医学 |
Outline of Final Research Achievements |
Genome-wide association studies (GWAS) have reported an association between schizophrenia and rs12807809 of the neurogranin (NRGN) gene. We have found that an rs12807809-rs12278912 haplotype of the gene is associated with schizophrenia in a Japanese population. The intellectual abilities of the high-risk TG/TG diplotype of the neurogranin gene were lower compared to those with the non-risk TA/TA diplotype. Our findings also suggested that the genome-wide associated genetic risk variant in the NRGN gene may be related to a small gray matter volume in the left anterior cingulate cortex in patients with schizophrenia. The lack of linkage between the risk gene polymorphisms and the expression levels of their major transcripts suggests that the control of pan mRNA levels may not be a prominent mechanism by which the genes identified in the GWAS contribute to the pathophysiology of schizophrenia.
|
Report
(4 results)
Research Products
(52 results)
-
[Journal Article] Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes.2014
Author(s)
Ohi K, Hashimoto R, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M.
-
Journal Title
Schizophr Bull.
Volume: 41
Issue: 4
Pages: 909-18
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Changes in plasma D-serine, L-serine, and glycine levels in treatment-resistant schizophrenia before and after clozapine treatment.2014
Author(s)
Yamamori H, Hashimoto R, Fujita Y, Numata S, Yasuda Y, Fujimoto M, Ohi K, Umeda-Yano S, Ito A, Ohmori T, Hashimoto K, Takeda M.
-
Journal Title
Neurosci Lett.
Volume: 582
Pages: 93-98
Related Report
Peer Reviewed
-
[Journal Article] Genetic risk variants of schizophrenia associated with left superior temporal gyrus volume.2014
Author(s)
Ohi K, Hashimoto R, Ikeda M, Yamashita F, Fukunaga M, Nemoto K, Ohnishi T, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Watanabe Y, Iwata N, Weinberger DR, Takeda M.
-
Journal Title
Cortex.
Volume: 58
Pages: 23-26
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] A functional polymorphism of the GTP cyclohydrolase 1 gene predicts attention performance.2014
Author(s)
Yasuda Y, Hashimoto R, Ohi K, Yamamori H, Fujimoto M, Umeda-Yano S, Fujino H, Fukunaga M, Horiguchi M, Takeda M, Ichinose H.
-
Journal Title
Neurosci Lett.
Volume: 566
Pages: 46-49
Related Report
Peer Reviewed
-
[Journal Article] Performance on the Wechsler Adult Intelligence Scale-III in Japanese patients with schizophrenia.2014
Author(s)
Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Umeda-Yano S, Higuchi A, Hibi Y, Matsuura Y, Hashimoto R, Takeda M, Imura O.
-
Journal Title
Psychiatry Clin Neurosci.
Volume: 68
Pages: 534-541
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia : evidences from voxel based morphometry and mutation screening.2012
Author(s)
Aleksic B, Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N
-
Journal Title
Schizophrenia Bulletin
Volume: 39
Issue: 3
Pages: 39-39
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia2012
Author(s)
Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H
-
Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B(4)
Issue: 4
Pages: 456-464
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis2012
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohnuma T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M
-
Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B(4)
Issue: 4
Pages: 405-413
DOI
Related Report
Peer Reviewed
-
[Journal Article] Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients2012
Author(s)
Koide T, Banno M, Aleksic B, Yamashita S, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Nakamura Y, Okada T, Ikeda M, Ohi K, Yasuda Y, Hashimoto R, Inada T, Ujike H, Iidaka T, Suzuki M, Takeda M, Iwata N, Ozaki N
-
Journal Title
PLoS One
Volume: 7(5)
Issue: 5
Pages: e36836-e36836
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-