Analysis of mice that carry disruption in Disc1, a schizophrenia risk gene
| Project/Area Number |
24591681
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University (2013-2014)
Okayama University (2012) |
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Principal Investigator |
MIYOSHI Ko 大阪大学, 連合小児発達学研究科, 助教 (90362996)
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| Co-Investigator(Kenkyū-buntansha) |
WAKANA Shigeharu 独立行政法人理化学研究所, バイオリソースセンター, チームリーダー (90192434)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Disc1 |
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| Outline of Final Research Achievements |
Disc1 is a risk gene of schizophrenia, a common psychiatric disease. In this research, difference between Disc1-lacking mice and wild-type mice was analyzed. No significant difference was found in regard to the cell architecture and neurite extension of neurons in various brain regions, and to neurogenesis in the developing cerebral cortex and in the hippocampal dentate gyrus of adult mice. In the behavior tests implicated as a hallmark for psychiatric disorders, Disc1-lacking mice demonstrated higher locomotor activity and a lower score in the contextual fear conditioning compared to wild-type mice.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Physiological ER stress mediates the differentiation of fibroblasts.2015
Author(s)
Matsuzaki S, Hiratsuka T, Taniguchi M, Shingaki K, Kubo T, Kiya K, Fujiwara T, Kanazawa S, Kanematsu R, Maeda T, Takamura H, Yamada K, Miyoshi K, Hosokawa K, Tohyama M, Katayama T.
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lack of dopaminergic inputs elongates the primary cilia of striatal neurons.2014
Author(s)
2.Miyoshi K, Kasahara K, Murakami S, Takeshima M, Kumamoto N, Sato A, Miyazaki I, Matsuzaki S, Sasaoka T, Katayama T, Asanuma M.
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Journal Title
PLoS One
Volume: 9(5)
Issue: 5
Pages: e97918-e97918
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Targeting 5-HT1A receptors in astrocytes to protect dopaminergic neurons in parkinsonian models.2013
Author(s)
Miyazaki, I., Asanuma, M., Murakami, S., Takeshima, M., Torigoe, N., Kitamura, Y. and Miyoshi, K.
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Journal Title
Neurobiol. Dis.
Volume: 59
Pages: 244-256
DOI
Related Report
Peer Reviewed
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