Neuronal Cellular Response to Behavioral Stress
Project/Area Number |
24591690
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | National Defense Medical College |
Principal Investigator |
NIBUYA Masashi 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 講師 (00228256)
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Co-Investigator(Kenkyū-buntansha) |
TODA Hiroyuki 防衛医科大学校, その他の部局等, 助教 (00610677)
NOMURA Soichiro 防衛医科大学校, その他の部局等, 教授 (80113091)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | stress / antidepressant / autophagy / depression / neurotrophic factor / PTSD / ストレス / うつ病 / オートファジー / BDNF / VEGF / アポトーシス / 抗うつ薬 / 細胞死 |
Outline of Final Research Achievements |
Three years research period resulted in four publications. 1) We reported the protective profile of paroxetine belonging to SSRIs on the gastromucosal epithelium. 2) We reported the enhanced autophagy signaling in the rat hippocampus by the electroconculsive sizure treatment. 3) We reported the significantly decreased plasma BDNF and VEGF concentration after the stressful ranger training in the Japan Self Defense Force. 4) We reported the enhanced autophagy signaling in the rat hippocampus by environmentally enriched housing conditions.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Therapeutic effect of paroxetine on stress-induced gastric lesions in mice.2012
Author(s)
Takahashi T, Suzuki G, Nibuya M*, Tanaka T, Nozawa H, Hatano B, Takahashi Y, Shimizu K, Yamamoto T, Tachibana S, Nomura S.
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 36
Pages: 39-43
Related Report
Peer Reviewed
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