Neuronal Cellular Response to Behavioral Stress

• Project/Area Number: 24591690
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: National Defense Medical College
• Principal Investigator: NIBUYA Masashi 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 講師 (00228256)
• Co-Investigator(Kenkyū-buntansha): TODA Hiroyuki 防衛医科大学校, その他の部局等, 助教 (00610677) ; NOMURA Soichiro 防衛医科大学校, その他の部局等, 教授 (80113091)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: stress / antidepressant / autophagy / depression / neurotrophic factor / PTSD / ストレス / うつ病 / オートファジー / BDNF / VEGF / アポトーシス / 抗うつ薬 / 細胞死

Outline of Final Research Achievements

Three years research period resulted in four publications. 1) We reported the protective profile of paroxetine belonging to SSRIs on the gastromucosal epithelium. 2) We reported the enhanced autophagy signaling in the rat hippocampus by the electroconculsive sizure treatment. 3) We reported the significantly decreased plasma BDNF and VEGF concentration after the stressful ranger training in the Japan Self Defense Force. 4) We reported the enhanced autophagy signaling in the rat hippocampus by environmentally enriched housing conditions.

Research Products

• [Journal Article] Environmental enrichment enhances autophagy signaling in the rat hippocampus. (2014)
  • Author(s): Takahashi T, Shimizu K, Shimazaki K, Toda H, Nibuya M
  • Journal Title: Brain Res Volume: 1592 Pages: 113-123
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Decreased plasma brain-derived neurotrophic factor and vascular endothelial growth factor concentrations during military training. (2014)
  • Author(s): Suzuki G, Tokuno S, Nibuya M, Ishida T, Yamamoto T, Mukai Y, Tsumatori G, Scott D, Shimizu K
  • Journal Title: PLoS One Volume: 9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Maternal separation enhances conditioned fear and decreased the mRNA levels of the neurotensin receptor 1 gene with hypermethylation of this gene in the rat amygdala. (2014)
  • Author(s): Toda H, Boku S, Nakagawa S, Inoue T, Kato A, Takamura N, Song N, Nibuya M, Koyama T, Kusumi I
  • Journal Title: PLos One Volume: 9
  • NAID: 120005537461
  • Peer Reviewed / Open Access
• [Journal Article] Electroconvulsive seizures enhance autophagy signaling in rat hippocampus. (2014)
  • Author(s): Otabe H, Nibuya M* Shimazaki K, Toda H, Suzuki G, Nomura S, Shimizu K.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 50 Pages: 37-43
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Two cases of mild serotonin toxicity via 5-hydroxytryptamine 1A receptor stimulation. (2014)
  • Author(s): Nakayama H, Umeda S, Nibuya M*, Terao T, Nishijima K, Nomura S
  • Journal Title: Neuropsychiatr Dis Treat Volume: 10 Pages: 283-287
  • Peer Reviewed / Open Access
• [Journal Article] Decreased plasma brain-derived neurotrophic factor and vascular endothelial growth factor concentrations during military training. (2014)
  • Author(s): Suzuki G, Tokuno S, Nibuya M*, Ishida T, Yamamoto T, Mukai Y, Tsumatori G, Scott D, Shimizu K
  • Journal Title: PLoS One Volume: 9
  • Peer Reviewed
• [Journal Article] DNA methylation of neurotensin receptor1 gene in amygdala induced by maternal separation enhances conditioned fear in adult rats. (2014)
  • Author(s): Toda H, Boku S, Nakagawa S, Inoue T, Kato A, Takamura N, Song N, Nibuya M, Koyama T, Kusumi I
  • Journal Title: PLoS One Volume: in press
  • Peer Reviewed
• [Journal Article] Serotonin Syndrome Induced by 5-Hydroxytryptamine 1A Receptor Stimulation (2013)
  • Author(s): Hiroto Nakayama, Sumiyo Umeda, Masashi Nibuya, Takeshi Terao, Koichi Nishijima, Soichiro Nomura
  • Journal Title: PSYCHOPHARMACOLOGY BULLETIN Volume: 46 Pages: 1-7
  • Peer Reviewed
• [Journal Article] ストレスと神経脆弱性、可塑性の精神医学研究 (2013)
  • Author(s): 丹生谷正史
  • Journal Title: 精神科 Volume: 21 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Therapeutic effect of paroxetine on stress-induced gastric lesions in mice. (2012)
  • Author(s): Takahashi T, Suzuki G, Nibuya M*, Tanaka T, Nozawa H, Hatano B, Takahashi Y, Shimizu K, Yamamoto T, Tachibana S, Nomura S.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 36 Pages: 39-43
  • Peer Reviewed
• [Journal Article] うつ病の分子基盤を考える、抗うつ薬と神経新生 (2012)
  • Author(s): 丹生谷正史、楯林義孝
  • Journal Title: 精神科 Volume: 20 Pages: 649-653
  • Peer Reviewed