Neuroanatomic pathways associated with poststroke affective and apathetic depression.
| Project/Area Number |
24591715
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脳卒中後うつ病 / MRI / SPM / 抑うつ気分 / アパシー / 脳幹 / 基底核 / 左側前頭葉 / 前頭葉皮質 / 注意障害 / モノアミン / 脳血管性うつ病 / 注意機能 / 視床 / 神経回路網 |
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| Outline of Final Research Achievements |
METHODS: Magnetic resonance imaging acquisitions were obtained from 149 poststroke patients, who were assessed for affective and apathetic symptoms using the Hospital Anxiety and Depression Scale and the Apathy Scale, respectively. We created a statistical parametric map that displayed an association between lesion location and affective and apathetic symptoms.
RESULTS: Among the patients with higher depressive scores, the lesion overlap centered on the brainstem, left basal ganglia, and left frontal cortex. Among the patients with higher apathy scores, the lesion overlap centered on the brainstem and bilateral striatum. The overlap lesion for both affective and apathetic depression centered mainly on the brainstem; however, the two types of depression often did not overlap. CONCLUSIONS: Two core symptoms that can occur after stroke, affective and apathetic symptoms, appear to be associated with different monoaminergic neuroanatomic pathways (serotonergic and dopaminergic).
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] 脳卒中後うつ病の診断と治療2014
Author(s)
山下 英尚, 濱 聖司, 村上 太郎, 福本 拓治, 町野 彰彦, 志々田 一宏, 小早川 誠, 淵上 学, 吉野 敦雄, 岡本 泰昌, 山脇 成人
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Journal Title
精神科治療学
Volume: 29
Pages: 289-294
Related Report
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[Journal Article] Distinctive spontaneous regional neural activity in patients with somatoform pain disorder: A preliminary resting-state fMRI study.2014
Author(s)
Atsuo Yoshino, Yasumasa Okamoto , Yoshihiko Kunisato, Shinpei Yoshimura, Ran Jinnin, Yumi Hayashi, Makoto Kobayakawa, Mitsuru Doi, Kyoko Oshita, Ryuji Nakamura, Keisuke Tanaka, Hidehisa Yamashita, Masashi Kawamoto, Shigeto Yamawaki
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Journal Title
Psychiatry Research: Neuroimaging
Volume: 221
Issue: 3
Pages: 246-248
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sadness enhances the experience of pain and affects pain-evokedcortical activities : an MEG study.2012
Author(s)
Yoshino A, Okamoto Y, Onoda K, Shishida K, Yoshimura S, Kunisato Y, Demoto Y, Okada G, Toki S, Yamashita H, Yamawaki S.
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Journal Title
The Journal of Pain
Volume: 13
Issue: 7
Pages: 628-635
DOI
Related Report
Peer Reviewed
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[Presentation] 脳卒中後のうつと不安2015
Author(s)
山下英尚、濱聖司、村上太郎、藤川徳美、山脇成人
Organizer
第7回日本不安症学会
Place of Presentation
広島
Year and Date
2015-02-14 – 2015-02-15
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