Brain imaging study of temperaments associated with bipolar spectrum

• Project/Area Number: 24591723
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Oita University
• Principal Investigator: TERAO Takeshi 大分大学, 医学部, 教授 (80217413)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 発揚気質 / 循環気質 / 脳画像 / 気質 / 気分障害 / 双極性スペクトラム / ｆMRI / 双極性障害 / 光 / 明暗 / FDG-PET / fMRI

Outline of Final Research Achievements

Hyperthymic temperament subjects received more sunshine whereas cyclothymic temperament subjects received less sunshine. Hyperthymic subjects had brightness preference while more sunshine incresed hyperthymic tendency. Magnetic resonance imaging studies revealed that hyperthimic temperament may be associated with neural correlates from the left medial frontal gyrus to the left inferior orbitofrontal cortex whereas cyclothymic temperament may be associated with neural correlates from the left medial frontal gyrus to the left lingual gyrus.

Research Products

• [Journal Article] Identification of the neural correlates of cyclothymic temperament using a working memory task in fMRI. (2015)
  • Author(s): Kodama K, Terao T, et al.
  • Journal Title: J Affect Disord Volume: 171 Pages: 1-5
  • DOI: 10.1016/j.jad.2014.09.009
  • Peer Reviewed
• [Journal Article] 双極性障害における気分安定薬の使い分け (2015)
  • Author(s): 寺尾 岳
  • Journal Title: 臨床精神薬理 Volume: 18 Pages: 265-270
• [Journal Article] Identification of the neural correlates of cyclothymic temperament using an esthetic judgment for paintings task in fMRI (2014)
  • Author(s): Mizokami Y, Terao T, et al.
  • Journal Title: J Affect Disord Volume: 162 Pages: 47-50
  • DOI: 10.1016/j.jad.2014.07.037
  • Peer Reviewed
• [Journal Article] Difference in brain activations during appreciating paintings and photographic analogs. (2014)
  • Author(s): Mizokami Y, Terao T, et al.
  • Journal Title: Front Hum Neurosci Volume: 8 Pages: 478-478
  • DOI: 10.3389/fnhum.2014.00478
  • Peer Reviewed
• [Journal Article] 双極性障害患者の認知機能障害は、日常生活機能や社会的転帰にどのように影響するか (2014)
  • Author(s): 寺尾 岳
  • Journal Title: 精神科 Volume: 24 Pages: 391-398
• [Journal Article] Association between affective temperaments and regional gray matter volume in healthy subjects. (2014)
  • Author(s): Hatano K,Terao T,Hoaki N,Kohno K,Araki Y,Mizokami Y,Kodama K,Harada M,Fujiki M,Shimomura T,Hayashi T
  • Journal Title: Journal of Affective Disorders Volume: 155 Pages: 169-73
  • DOI: 10.1016/j.jad.2013.10.045
  • Peer Reviewed
• [Journal Article] Hyperthymic temperament and rapid reaction time in brightness preference. (2013)
  • Author(s): Kodama K,Harada M,Terao T,Hatano K,Kohno K,Araki Y,Mizokami Y,Hoaki N,Shimomura T,Fujiki M,Kochiyama T
  • Journal Title: Journal of Affective Disorders Volume: 151(3) Issue: 3 Pages: 914-9
  • DOI: 10.1016/j.jad.2013.07.038
  • Peer Reviewed
• [Journal Article] Hyperthymic temperament and brightness preference in healthy subjects:further evidence for involvement of left inferior orbitofrontal cortex in hyperthymic temperament. (2013)
  • Author(s): Harada M,Terao T,Hatano K,Kohno K,Araki Y,Mizokami Y,Kodama K,Hoaki N,Arasaki M,Shimomura T,Fujiki M,Kochiyama T
  • Journal Title: Journal of Affective Disorders Volume: 151(2) Issue: 2 Pages: 763-8
  • DOI: 10.1016/j.jad.2013.06.017
  • Peer Reviewed
• [Journal Article] Hyperthymic temperament and brightness judgment in healthy subjects:Involvement of left inferior orbitofrontal cortex. (2013)
  • Author(s): Harada M,Hoaki N,Terao T,Hatano K,Kohno K,Araki Y,Mizokami Y,Kodama K,Toyokawa K,Izumi T,Arasaki M,Shimomura T,Fujiki M,Kochiyama T
  • Journal Title: Journal of Affective Disorders Volume: 151(1) Issue: 1 Pages: 143-8
  • DOI: 10.1016/j.jad.2013.05.066
  • Peer Reviewed
• [Journal Article] Type A behavior pattern:Bortner scale vs.Japanese-original questionnaires. (2012)
  • Author(s): Yumei Wang, Takeshi Terao, Nobuhiko Hoaki, Shinjiro Goto, Yasuo Araki, Kentaro Kohno
  • Journal Title: Journal of Affective Disorders Volume: 142 Issue: 1-3 Pages: 351-354
  • DOI: 10.1016/j.jad.2012.03.049
  • Peer Reviewed
• [Journal Article] Latitude effect on bipolar temperaments. (2012)
  • Author(s): Kentaro Kohno, Nobuhiko Hoaki, Takeshi Inoue, Yukiei Nakai, Atsuhito Toyomaki, Yasuo Araki, Koji Hatano, Takeshi Terao
  • Journal Title: Jornal of Affective Disorders Volume: 142 Issue: 1-3 Pages: 53-56
  • DOI: 10.1016/j.jad.2012.03.052
  • Peer Reviewed
• [Journal Article] Bipolar spectrum: Relevant psychological and biological factors (2012)
  • Author(s): Tekeshi Terao
  • Journal Title: World Journal of Psychiatry Volume: 22(5) Issue: 5 Pages: 71-73
  • DOI: 10.5498/wjp.v2.i5.71
  • Peer Reviewed
• [Journal Article] 双極スペクトラム障害は過少診断か～治療的見地から～ (2012)
  • Author(s): 寺尾 岳
  • Journal Title: Depression Frontier Volume: 10(1) Pages: 9-12
• [Journal Article] 双極性障害の薬物療法と睡眠 (2012)
  • Author(s): 寺尾 岳
  • Journal Title: 睡眠医療 Volume: 6(2) Pages: 199-204
• [Presentation] 双極性気質に関する最近の話題 (2014)
  • Author(s): 寺尾 岳
  • Organizer: 第34回日本精神科診断学会
  • Place of Presentation: 大和屋本店（愛媛）
  • Year and Date: 2014-11-13
• [Presentation] 双極性気質に関する最近の話題 (2014)
  • Author(s): 寺尾 岳
  • Organizer: 第36回日本生物学的精神医学会・第57回日本神経化学会大会
  • Place of Presentation: 奈良文化会館（奈良）
  • Year and Date: 2014-09-29
• [Presentation] Hyperthymic Temperament and Sunshine: A Study of 3 Regions in Japan. (2014)
  • Author(s): Kohno K, Terao T, et al.
  • Organizer: IRPB 2014-International Review of Psychosis & Bipolarity
  • Place of Presentation: Divani Caravel Hotel（Greece）
  • Year and Date: 2014-05-11
• [Presentation] Hyperthymic Temperament and Brightness Preference. (2014)
  • Author(s): Makino M, Terao T, et al.
  • Organizer: IRPB 2014-International Review of Psychosis & Bipolarity
  • Place of Presentation: Divani Caravel Hotel（Greece）
  • Year and Date: 2014-05-11
• [Presentation] The specefic neural correlates of aesthetic judgment for paintings: in relation to bipolar temperaments. (2014)
  • Author(s): Mizokami Y, Terao T, et al.
  • Organizer: IRPB 2014-International Review of Psychosis & Bipolarity
  • Place of Presentation: Divani Caravel Hotel（Greece）
  • Year and Date: 2014-05-11
• [Presentation] 双極性障害の診断：軽躁状態や気質に焦点をあてて (2012)
  • Author(s): 寺尾 岳、田中 輝明、帆秋 伸彦、秦野 浩司
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 北海道札幌コンベンションセンター
• [Book] 今日の治療指針 双極性障害、躁状態（頁：878－879） (2013)
  • Author(s): 寺尾 岳
  • Total Pages: 2
  • Publisher: 医学書院
• [Book] Bipolar Disorder10 双極性障害の多様性：混合状態に焦点をあてて（頁：57－67） (2012)
  • Author(s): 寺尾 岳
  • Total Pages: 11
  • Publisher: アルタ出版株式会社
• [Book] 気分障害の薬理・生化学～うつ病の脳内メカニズム研究：進歩と挑戦～ 気分障害におけるセロトニンの役割(頁：40－55) (2012)
  • Author(s): 寺尾 岳、帆秋 伸彦
  • Total Pages: 16
  • Publisher: 医薬ジャーナル社
• [Book] 気分障害の薬理・生化学～うつ病の脳内メカニズム研究：進歩と挑戦～ 発揚気質と光感受性(頁：322－323) (2012)
  • Author(s): 寺尾 岳、帆秋 伸彦
  • Total Pages: 2
  • Publisher: 医薬ジャーナル社