| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
DFosB is transcriptional factor, which is accumulated in specific brain regions by chronic or repeated stimulation of stress or addictive drugs. We have reported DFosB makes a role for anti-depressant. However, overexpressed DFosB mRNA codes DFosB and N-terminal lacking D2DFosB, and expresses at similar level. We tried to reveal which one has more important role for depression and cocaine addiction by respective expression using AAV in nucleus accumbens. In results, DFosB enhanced cocaine addiction after social defeat stress, and works as anti-depressant, but, D2DFosB inhibit such type of cocaine addiction and does not work as anti-depressant.
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