Creation of novel model mice for dementia research and development of new medicines for dementia treatment.
Project/Area Number |
24591738
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Tokyo Metropolitan Institute of Medical Science |
Principal Investigator |
HOSOKAWA Masato 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主席研究員 (00435116)
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Co-Investigator(Renkei-kenkyūsha) |
AKIYAMA Haruhiko 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 参事研究員 (20231839)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 認知症 / TDP-43 / tau / 疾患モデルマウス / タンパク質異常凝集 / グラニュリン / 前頭側頭葉変性症 / プログラニュリン / タウ / アルツハイマー病 / トランスジェニックマウス |
Outline of Final Research Achievements |
Nobel mice model regarding dementa research were produced for discovering effective drugs. These mice over expressed neurodegenerative diseases associated protein by doxycycline. The abnormal aggregations of these proteins have not observed in neuronal cells yet because aging of mice is not sufficient or other reasons. The results of the other model mice suggest that granulin mutations might contribute to the pathogenesis or be risk factors for tauopathies, including Alzheimer’s disease or corticobasal degeneration.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] An autopsied case of corticobasal degeneration showing severe cerebral atrophy over a protracted disease course of 16 years2014
Author(s)
Kondo D, Hino H, Shibuya K, Fujisawa K, Kosaka K, Hirayasu Y, Yamamoto R, Kasanuki K, Minegishi M, Sato K, Hosokawa M, Arai T, Arai H, Iseki E
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Journal Title
Neuropathology
Volume: Epub ahead of print
Issue: 3
Pages: 280-288
DOI
Related Report
Peer Reviewed
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[Journal Article] Tau accumulation in the nucleus accumbens in tangle-predominant dementia2014
Author(s)
Kawakami I, Hasegawa M, Arai T, Ikeda K, Oshima K, Niizato K, Aoki N, Katsuse O, Higashi S, Hosokawa M, Hirayasu Y, Akiyama H
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Journal Title
Acta Neuropathol
Volume: Commun 2
Issue: 1
Pages: 40-40
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases.2013
Author(s)
Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H.
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Journal Title
Neurol. Sci.
Volume: 335
Issue: 1-2
Pages: 89-95
DOI
Related Report
Peer Reviewed
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[Presentation] タウオパチー病理変化の基礎2013
Author(s)
新井哲明, 河上緒, 小林禅, 野中隆, 長谷川成人, 細川雅人, 秋山治彦, 池田研二, 朝田隆
Organizer
第32回 日本認知症学会
Place of Presentation
松本 キッセイ文化ホール
Related Report
Invited
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