| Project/Area Number |
24591746
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
TAMURA Hajime 東北大学, 医学(系)研究科(研究院), 非常勤講師 (20333817)
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| Co-Investigator(Kenkyū-buntansha) |
OTA Hideki 東北大学, 病院, 助教 (40586905)
NAKAMURA Yasuhiro 東北大学, 大学院医学系研究科, 准教授 (80396499)
WATANABE Mika 東北大学, 病院, 准教授 (20292344)
YOSHMURA Shinichi 岐阜大学, 医学(系)研究科(研究院), 准教授 (40240353)
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| Research Collaborator |
OBARA Makoto
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 動脈硬化 / 動脈プラーク / MRI / 緩和時間 / 拡散係数 / プラークイメージング / 縦緩和時間 |
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| Outline of Final Research Achievements |
Carotid-plaque tissue characterization has an important role for patients’ management. Main characteristics of vulnerable plaque includes thin fibrous cap with large lipid-rich/necrotic core, active inflammation, fissured plaque, intraplaque hemorrhage. This study showed that combination of apparent diffusion coefficient and longitudinal relaxation time obtained by MRI can differentiate lipid-rich/necrotic core, intraplaque hemorrhage and fibrous tissue.
A tool running on PC with a commercial software was made for MRI-virtual histology: giving an image depicting the three tissue components based on the MRI data.
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