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Establishment of clinical analysis method for higher brain dysfunctions using ASL-MRI

Research Project

Project/Area Number 24591774
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionResearch Institute, International Medical Center of Japan (2014)
Saga University (2012-2013)

Principal Investigator

NOGUCHI Tomoyuki  独立行政法人国立国際医療研究センター, その他部局等, その他 (40380448)

Co-Investigator(Kenkyū-buntansha) 浅見 豊子  佐賀大学, 医学部, 准教授 (20222599)
入江 裕之  佐賀大学, 医学部, 教授 (50284493)
西原 正志  佐賀大学, 医学部, 助教 (50516557)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsASL / MRI / 脳機能画像 / 高次脳機能障害 / もやもや病 / 髄膜脳炎 / 脳出血 / 脳血流 / ASL-MRI / 被殻出血 / モヤモヤ病 / 被殼出血 / 急性髄膜脳炎
Outline of Final Research Achievements

Higher brain dysfunctions such as decreased cognitive function, aphasia or memory impairment cause daily life disability or executive function impairment, which leads difficulty to have work opportunities or return to uneventful life because of excessive burden. This fact has drawn considerable attention as one of social issues. PET or SPECT as conventional brain function nuclear medicine examinations cannot be frequently performed in all patients because of expensive examinations costs and limited spread of equipments. ASL-MRI is one of MRI imaging methods measuring cerebral blood flow non-invasively. We explored the utility of ASL-MRI as an alternative imaging methods for evaluating higher brain dysfunctions.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (36 results)

All 2015 2014 2013 2012

All Journal Article (16 results) (of which Peer Reviewed: 10 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Invited: 5 results) Book (6 results)

  • [Journal Article] Noninvasive method for mapping CVR in moyamoya disease using ASL-MRI.2015

    • Author(s)
      Noguchi T, Kawashima M, Nishihara M, Egashira Y, Azama S, Irie H
    • Journal Title

      Eur J Radiol.

      Volume: xx Issue: 6 Pages: 1-7

    • DOI

      10.1016/j.ejrad.2015.03.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Technical Perspective for Understanding Quantitative Arterial Spin-labeling MR Imaging using Q2TIPS2015

    • Author(s)
      Noguchi T, Nishihara M, Hara Y, Hirai T, Egashira Y, Azama S, Irie H.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 14 Issue: 1 Pages: 1-12

    • DOI

      10.2463/mrms.2013-0064

    • NAID

      130004935523

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Basal Ganglia Cerebral Microbleeds and Global Cognitive Function: The Kashima Scan Study.2014

    • Author(s)
      Yakushiji Y, Noguchi T, Charidimou A, Eriguchi M, Nishihara M, Hara M, Nanri Y, Horikawa E, Nishiyama M, Werring DJ, Hara H.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 24 Issue: 2 Pages: 431-439

    • DOI

      10.1016/j.jstrokecerebrovasdis.2014.09.015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamic contrast-enhanced MRI (DCE) for spinal dural arteriovenous fistula: a case report [English and Japanese]2014

    • Author(s)
      Noguchi T, Egashira Y, Nishihara M, Takase Y, Irie H
    • Journal Title

      Neuro-Imaging Conference Chikugo-Saga Shoureishu

      Volume: 18 Pages: 23-30

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Posterior condylar canals and posterior condylar emissary veins: Microsurgical and CT anatomical study".2014

    • Author(s)
      Matsushima K, Kawashima M, Matsushima T, Hiraishi T, Noguchi T, Kuraoka A.
    • Journal Title

      Neurosurg Review

      Volume: 37 Issue: 1 Pages: 115-126

    • DOI

      10.1007/s10143-013-0493-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Arterial spin-labeling MR imaging in moyamoya disease compared with clinical assessments and other MR imaging finings2013

    • Author(s)
      Noguchi T, Kawashima M, Nishihara M, Hirai T, Matsushima T, Irie H
    • Journal Title

      European Journal of Radiololgy

      Volume: 82 Issue: 12 Pages: e840-e847

    • DOI

      10.1016/j.ejrad.2013.08.040

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 数式とシェーマから読み解くASL-MRIの理論的背景:Q2TIPS2013

    • Author(s)
      野口 智幸、西原 正志、原 由紀子、平井 徹良、江頭 秀哲、安座 間真也、入江 裕之
    • Journal Title

      日本磁気共鳴医学会雑誌

      Volume: 33 Pages: 147-157

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 脳の画像診断:ASLはどこまで脳核医学画像に迫れるか?2013

    • Author(s)
      野口 智幸、西原正志、原 由紀子、大塚貴輝、江頭秀哲、山口 健、平井徹良、北野 庸、入江裕之.
    • Journal Title

      臨床放射線

      Volume: 58 Pages: 1211-1220

    • NAID

      40019801298

    • Related Report
      2013 Research-status Report
  • [Journal Article] 脳血流画像(ASL画像).2013

    • Author(s)
      野口 智幸、大塚貴輝、西原正志、江頭秀哲、山口 健、平井徹良、原 由紀子、北野 庸、入江裕之.
    • Journal Title

      精神科

      Volume: 22 Pages: 382-387

    • Related Report
      2013 Research-status Report
  • [Journal Article] A case of multiple gliomas with rare histological subtypes [English and Japanese].2013

    • Author(s)
      Noguchi T, Nishihara M, Irie H.
    • Journal Title

      Neuro-Imaging Conference Chikugo-Saga Shoureishu

      Volume: 13 Pages: 15-18

    • Related Report
      2013 Research-status Report
  • [Journal Article] Joint effect of hypertension and lifestyle-related risk factors on the risk of brain microbleeds in healthy individuals2013

    • Author(s)
      Hara M, Yakushiji Y, Nannri H, Sasaki S, Noguchi T, Nishiyama M, Hirotsu T, Nakajima J, Hara H
    • Journal Title

      Hypertens Res

      Volume: 36 Issue: 9 Pages: 789-794

    • DOI

      10.1038/hr.2013.26

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] CT-gastrography for early gastric cancer visualized by Wall-Carving technique; Value of portal phase contrast-enhanced MDCT2013

    • Author(s)
      Kitano I, Noguchi T, Mizuguchi M, Nishihara M, Hara Y, Azama S, Yamaguchi K, Hirai T, Takase Y, Liu L, Noshiro H, Fujimoto K, Irie H
    • Journal Title

      Fukuoka Acta Med.

      Volume: 104 Pages: 89-98

    • NAID

      120005315165

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of multiple gliomas with rare histological subtypes [English and Japanese]2013

    • Author(s)
      Noguchi T, Nishihara M, Irie H
    • Journal Title

      Neuro-Imaging Conference Chikugo-Saga Shoureishu

      Volume: 13 Pages: 8-10

    • Related Report
      2012 Research-status Report
  • [Journal Article] 脳血流画像(ASL画像)2013

    • Author(s)
      野口 智幸、大塚貴輝、西原正志、江頭秀哲、山口 健、平井徹良、原 由紀子、北野 庸、入江裕之
    • Journal Title

      精神科

      Volume: 22 Pages: 382-387

    • Related Report
      2012 Research-status Report
  • [Journal Article] Narrowed Petrous Carotid Canal Detection for the Early Diagnosis of Moyamoya Disease2012

    • Author(s)
      Motoshima S, Noguchi T, Kawashima M, Ooishi M, Irie H, Nishihara M, Matsushima T, Kudo S
    • Journal Title

      Fukuoka Acta Med.

      Volume: 103 Pages: 206-214

    • NAID

      120004929974

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distributional impact of brain microbleeds on global cognitive function in adults without neurological disorder.2012

    • Author(s)
      Yakushiji Y, Noguchi T, Hara M, Nishihara M, Eriguchi M, Nanri Y, Nishiyama M, Hirotsu T, Nakajima J, Kuroda Y, Hara H
    • Journal Title

      Stroke

      Volume: 43 Issue: 7 Pages: 1800-1805

    • DOI

      10.1161/strokeaha.111.647065

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ASL-MRIパーフェクトガイド2014

    • Author(s)
      野口 智幸
    • Organizer
      第56回 九州MRI研究会
    • Place of Presentation
      パピヨン24(福岡市)
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Arterial Spin-Labeling MR ImagingIn Putaminal Hemorrhage: A Pilot Study2014

    • Author(s)
      Noguchi T, Yakushiji Y, Nishihara M, Egashira Y, Azama S, Ootsuka T, Hirai T, Kajihara T, Irie H
    • Organizer
      17th Workshop of German-Japanese Radiological Affilliation
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2014-06-06 – 2014-06-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Arterial Spin-Labeling MR Imaging In Putaminal Hemorrhage: A Pilot Study2014

    • Author(s)
      Noguchi T, Nishihara M, Egashira Y, Azama S, Kajihara T, Hirai T, Kitano I, Irie H
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜 (横浜市)
    • Year and Date
      2014-04-13 – 2014-04-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Diffusion tensor imaging of the breast based on readout-segmented echo-planar imaging2014

    • Author(s)
      Yamaguchi K, Nakazono T, Noguchi T, Egashira R, Hara H, Hirai T, Nakamura J, Noshiro H, Irie H.
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜 (横浜市)
    • Year and Date
      2014-04-13 – 2014-04-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] ASL を用いた脳血流による高次脳機能障害の評価2014

    • Author(s)
      野口 智幸
    • Organizer
      第37回日本脳神経CI学会総会
    • Place of Presentation
      ソニックシティ(さいたま市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Visual assessment of ASL-MRI for acute ischemic stroke2013

    • Author(s)
      Noguchi T, Irie H, Nishihara M, Hirai T, Mizuguchi M, Hara Y
    • Organizer
      99th Scientific Assembly and Annual Meeting of Radiological Society of North America
    • Place of Presentation
      Chicago, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Visual Assessment of Arterial Spin-labeling MR Imaging (ASL-MRI) for Brain Tumors and Tumor-like Diseases2012

    • Author(s)
      Noguchi T, Irie H, Ootsuka T, Nishihara M, Hirai T, Kitano I
    • Organizer
      98th Scientific Assembly and Annual Meeting of Radiological Society of North America
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Clinical validation study for cerebral blood flow value variance between different numbers of measurements of arterial spin labeling MR imaging. [Oral presentation]2012

    • Author(s)
      Noguchi T, Irie H, Ootsuka T, Nishihara M, Hirai T, Kitano I
    • Organizer
      Scientific Assembly and Annual Meeting of Radiological Society of North America
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Arterial Spin-Labeling MR ImagingIn Putaminal Hemorrhage: A Pilot Study2012

    • Author(s)
      Noguchi T, Nishihara M, Hirai T, Kitano I, Irie H
    • Organizer
      Scientific Assembly and Annual Meeting of Radiological Society of North America
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 急性髄膜脳炎のASL-MRI所見についての先行的検討2012

    • Author(s)
      野口 智幸、入江 裕之、西原 正志、平井 徹良、北野 庸
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜 (横浜市)
    • Related Report
      2012 Research-status Report
  • [Presentation] オルダミンによる直接穿刺硬化療法後に局所の著明な腫脹を来した上唇部血管腫の2例2012

    • Author(s)
      野口智幸、檀上 敦、西原正志、山下佳雄、後藤昌昭、江頭秀哲、入江裕之
    • Organizer
      第175回 日本医学放射線学会九州地方会
    • Place of Presentation
      鹿児島大学 (鹿児島市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 脳:脳の画像診断:CT・MRIはどこまで脳核医学画像に迫れるのか?2012

    • Author(s)
      野口 智幸
    • Organizer
      第52回日本核医学会技術総会
    • Place of Presentation
      さっぽろ芸術文化の館/ロイトン札幌(札幌市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ASLの基礎と臨床:脳腫瘍への応用2012

    • Author(s)
      野口 智幸
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 脳卒中の画像診断と予後2012

    • Author(s)
      野口 智幸
    • Organizer
      第43回ニューロイメージングカンファランス
    • Place of Presentation
      唐津ロイヤルホテル(唐津市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 圧倒的画像数で診る!頭部疾患画像アトラス2014

    • Author(s)
      野口 智幸
    • Total Pages
      430
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] 圧倒的画像数で診る!頭部疾患画像アトラス2014

    • Author(s)
      野口 智幸
    • Total Pages
      430
    • Publisher
      羊土社(東京)
    • Related Report
      2013 Research-status Report
  • [Book] メジカルビュー社2014

    • Author(s)
      西原 正志、野口 智幸
    • Total Pages
      412
    • Publisher
      新頭部画像診断の勘ドコロ
    • Related Report
      2013 Research-status Report
  • [Book] 画像診断ガイドライン 2013年度版2013

    • Author(s)
      野口 智幸
    • Total Pages
      480
    • Publisher
      金原出版株式会社
    • Related Report
      2013 Research-status Report
  • [Book] メジカルビュー社2013

    • Author(s)
      野口 智幸
    • Total Pages
      276
    • Publisher
      頭部画像解剖 徹頭徹尾
    • Related Report
      2013 Research-status Report
  • [Book] In頭部画像解剖 徹頭徹尾 蓮尾金博2013

    • Author(s)
      野口 智幸
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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