Establishment of myocardial fibrosis quantification method using delayed contrast-enhanced MRI
| Project/Area Number |
24591776
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUEYOSHI Eijun 長崎大学, 病院(医学系), 講師 (40380894)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMOTO Ichiro 長崎大学, 医歯薬総合研究科(医学系), 准教授 (00225806)
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| Research Collaborator |
HAYASHIDA Takeshi
KOTAKE Takako
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | MRI / 心筋遅延造影法 / 心筋線維化 / 定量化法 / 心筋炎 / 遅延造影 / 高安動脈炎 / 心筋 / 線維化 / 心臓 |
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| Outline of Final Research Achievements |
To estimate diffuse myocardial fibrosis with cardiac MRI in patients with dilated cardiomyopathy (DCM) using myo- cardial T1 value.
Delayed enhancement imaging was performed in 52 patients with DCM and 10 control subjects to identify fibrosis using an inversion time scout sequence. The mean contrast-enhanced myocardial (M) T1 values of the pre and post contrast-enhanced myocardial and left ventricular lumen (L) of control and dilated cardiomyopathy cases were compared. The calculated post M T1 value, pre M T1 value-post M T1 value, and (pre M TI value-post M T1 value)/(pre L T1 value-post L T1 value) were significantly different between the patient group and the control group. (Pre M T1 value-post M T1 value)/(pre L T1 value-post L T1 value) was significantly the most re-lated to the left ventricular ejection fraction (r = 0.66, p < 0.0001). (Pre M T1 value-post M T1 value)/(pre L T1 value-post L T1 value) was the most reliable quantification method to estimate the severity of DCM.
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Report
(5 results)
Research Products
(6 results)
