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Development of new tumor PET probes: C-11-labeled aminoisobutyric acid and analogs

Research Project

Project/Area Number 24591803
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

TSUJI Atsushi  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (60303559)

Co-Investigator(Kenkyū-buntansha) KATO Koichi  独立行政法人国立精神, 神経医療研究センター・脳病態統合イメージングセンター, 室長 (50382198)
Co-Investigator(Renkei-kenkyūsha) SUZUKI Chie  独立行政法人放射線医学総合研究所, 分子イメージング研究センター・分子病態イメージング研究プログラム, 准研究員 (20637285)
SUDO Hitomi  独立行政法人放射線医学総合研究所, 分子イメージング研究センター・分子病態イメージング研究プログラム, 研究員 (10415416)
SUGYO Aya  独立行政法人放射線医学総合研究所, 分子イメージング研究センター・分子病態イメージング研究プログラム, 技術員 (00415415)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords核医学 / 腫瘍イメージング / PET薬剤 / 放射線治療 / PET / アミノ酸トランスポーター / 腫瘍画像診断
Outline of Final Research Achievements

PET with [11C]AIB has the potential for use in non-invasive evaluation of early therapeutic response after irradiation before morphological change of tumors. There was a significant correlation between [11C]AIB tumor uptake and SLC38A1 expression after irradiation. The radiosynthesis method of alpha-Ethyl[11C]methylglycine was developed. This radiotracer showed higher tumor-to-blood ratio compared with [11C]AIB and would be incorporated into cells mainly via different transporter systems. The efficient method of obtaining [11C]ethyl iodide was not established. Further study is needed for the method.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Preclinical assessment of early tumor response after irradiation by positron emission tomography with 2-amino-[3-11C]isobutyric acid2015

    • Author(s)
      Tsuji AB, Sugyo A, Sudo H, Suzuki C, Wakizaka H, Zhang MR, Kato K, Saga T
    • Journal Title

      Oncol Rep

      Volume: 33 Issue: 5 Pages: 2361-7

    • DOI

      10.3892/or.2015.3868

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] nhibition of radical reactions for an improved potassium tert-butoxide-promoted 11C-methylation strategy for the synthesis of α-11C-methyl amino acids2015

    • Author(s)
      Suzuki C, Kato K, Tsuji AB, Zhang MR, Arano Y, Saga T
    • Journal Title

      Journal of Labelled Compounds and Radiopharmaceuticals

      Volume: 58 Issue: 3 Pages: 127-32

    • DOI

      10.1002/jlcr.3259

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Preclinical Characterization of 5-Amino-4-Oxo-[6-11C]Hexanoic Acid as an Imaging Probe to Estimate Protoporphyrin IX Accumulation Induced by Exogenous Aminolevulinic Acid2014

    • Author(s)
      Suzuki C, Tsuji A, Kato K, Kikuchi T, Sudo H, Okada M, Sugyo A, Zhang MR, Arano Y, Saga T
    • Journal Title

      J Nucl Med

      Volume: 55 Issue: 10 Pages: 1671-7

    • DOI

      10.2967/jnumed.114.145086

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synthesis and in vitro cellular uptake of 11C-labeled 5-aminolevulinic acid derivative to estimate the induced cellular accumulation of protoporphyrin IX.2013

    • Author(s)
      Suzuki C, Kato K, Tsuji AB, Kikuchi T, Zhang MR, Arano Y, Saga T.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 23 Issue: 16 Pages: 4567-70

    • DOI

      10.1016/j.bmcl.2013.06.025

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of 2-amino-[3-11C]isobutyric acid and 2-deoxy-2-[18F]fluoro-D-glucose in nude mice with xenografted tumors and acute inflammation2012

    • Author(s)
      Tsuji AB, Kato K, Sugyo A, Okada M, Sudo H, Yoshida C, Wakizaka H, Zhang MR, Saga T
    • Journal Title

      Nucl. Med. Commun.

      Volume: 33 Issue: 10 Pages: 1058-1064

    • DOI

      10.1097/mnm.0b013e328356efb0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 5-アミノレブリン酸を使用した光線力学療法の治療効果を予測するPETプローブの開発に関する基礎的検討2013

    • Author(s)
      鈴木 千恵、 辻 厚至、 加藤 孝一、 菊池 達矢、 須尭 綾、 須藤 仁美、 荒野 泰、 佐賀 恒夫
    • Organizer
      日本薬学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 放射線治療効果評価における11C-AIB PETの有用性の小細胞肺癌モデルマウスでの検討

    • Author(s)
      辻 厚至, 須尭 綾, 須藤 仁美, 加藤 孝一, 張 明栄, 佐賀 恒夫
    • Organizer
      日本核医学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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