Development of small molecular radiolabeled probes for nuclear medical imaging of unstable plaques
| Project/Area Number |
24591813
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Cardiovascular Center Research Institute (2014)
Kyoto University (2012-2013) |
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Principal Investigator |
TEMMA TAKASHI 独立行政法人国立循環器病研究センター, 研究所, 室長 (90378787)
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| Co-Investigator(Kenkyū-buntansha) |
SAJI Hideo 京都大学, 薬学研究科, 教授 (40115853)
SHIOMI Masashi 神戸大学, 医学研究科, 准教授 (50226106)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 放射性医薬品 / 動脈硬化イメージング / 不安定プラーク |
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| Outline of Final Research Achievements |
This study aimed to develop small molecular radiolabeled probes for imaging Fatty Acid Binding Protein 4 (FABP4) and Matrix Metalloproteinase 12 (MMP12) in unstable plaques since FABP4 and MMP12 are promising candidates for molecular targeted therapy of atherosclerosis. 125I-TAP1 with triazolopyrimidine structure showed high FABP4 affinity and selectivity but showed high nonspecific accumulation in vitro. 18F-FTAP1 showing lower hydrophobicity rather than 125I-TAP1 maintained high affinity and selectivity toward FABP4 and succeeded in decrease of nonspecific accumulation in vitro. Besides, 18F-FTAP1 enabled in vivo imaging of FABP4 expression in mice by microPET/CT.
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Report
(4 results)
Research Products
(12 results)
