| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
I investigated the mechanisms and the protection methods of X-ray-induced delay of myotube formation. I evaluated the alterations of gene expressions of four key transcription factors and demonstrated the decrease in myogenin gene expression related to the X-ray-induced decrease in myotube formation. I also find that the cell cycle distributions and cell growth state of C2C12 cells affected the effects of X-ray irradiation on myotube formation. In addition, I showed that fibroblast growth factor and/or hepatocyte growth factor had the ability to protect the X-ray-induced decrease in myotube formation if these growth factors appropriately used in the point of concentration and/or time point, and so on.
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