Prediction of late rectal bleeding treated with radiotherapy for prostate cancer using biochemical marker.

• Project/Area Number: 24591846
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Sapporo Medical University
• Principal Investigator: SOMEYA Masanori 札幌医科大学, 医学部, 講師 (60404711)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 放射線直腸炎 / 前立腺癌 / 放射線治療 / 有害事象予測 / 直腸出血 / バイオマーカー / マイクロRNA / DNA修復タンパク / 放射線感受性予測

Outline of Final Research Achievements

To predict individual radiosensitivity of normal tissue, we collected and analysed the expressions of Ku80 mRNA and radiation-induced microRNA-99a in peripheral blood lymphocytes treated with radiotherapy for prostate cancer. Peripheral blood lymphocytes were collected from 97 prostate cancer patients with at least 3 year of follow-up after radiotherapy. As a result, a combination of low Ku80 mRNA expression and highly-induced microRNA-99a could precisely detect grade 2 or more of radiation-induced late rectal bleeding. In conclusion, a combination of low Ku80 expression and highly-induced microRNA-99a expression could be a promising marker for predicting rectal bleeding after radiotherapy.

Research Products

• [Journal Article] Results and DVH analysis of late rectal bleeding in patients treated with 3D-CRT or IMRT for localized prostate cancer (2015)
  • Author(s): Someya M, Hori M, Tateoka K, Nakata K, Takagi M, Saito M, Hirokawa N, Hareyama M, Sakata K.
  • Journal Title: Journal of Radiation Research Volume: 56 Issue: 1 Pages: 122-127
  • DOI: 10.1093/jrr/rru080
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relation between Ku80 and microRNA-99a expression and late rectal bleeding after radiotherapy. (2015)
  • Author(s): Someya M, Yamamoto H, Nojima M, Hori M, Tateoka K, Nakata K, Takagi M, Saitoh M, Hirokawa N, Tokino T, Sakata K
  • Journal Title: Radiotherapy and Oncology Volume: in press Issue: 2 Pages: 235-239
  • DOI: 10.1016/j.radonc.2015.04.008
  • Peer Reviewed
• [Presentation] 末梢血リンパ球を用いた前立腺癌放射線治療後の直腸出血の予測 (2015)
  • Author(s): 染谷正則、堀正和、中田健生、高田優、坂田耕一
  • Organizer: 第27回日本放射線腫瘍学会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2015-12-11 – 2015-12-13
• [Presentation] Relation between Ku80 and microRNA-99a expression and late rectal bleeding after radiotherapy for prostate cancer (2015)
  • Author(s): Someya M, Nakata K, Hori M, Takada Y, Hasegawa T, Kitagawa M, Sakata K.
  • Organizer: 第74回日本医学放射線学会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2015-04-17 – 2015-04-19
• [Presentation] 放射線治療患者のリンパ球および血清を用いた治療効果および有害事象予測 (2015)
  • Author(s): 染谷正則
  • Organizer: 第8回Quantum Medicine研究会（茨城大学理学部公開シンポジウム）
  • Place of Presentation: 茨城大学理学部（茨城県・水戸市）
  • Year and Date: 2015-03-01
  • Invited
• [Presentation] 個人の放射線感受性予測を目指して (2014)
  • Author(s): 染谷 正則
  • Organizer: 第7回QUANTUM Medicine研究会
  • Place of Presentation: 茨城大学理学部
• [Presentation] 前立腺癌根治照射後の放射線直腸炎とDVH 解析 (2013)
  • Author(s): 染谷 正則
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森市リンクステーション青森