A study on the safety of short-term whole breast irradiation using the Field In-Field technique
| Project/Area Number |
24591851
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 乳癌 / 乳房温存療法 / 放射線治療 / 短期照射 / 癌 |
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| Outline of Final Research Achievements |
Purpose: To evaluate efficacy and safety of short-term radiotherapy (42.56 Gy/16 fractions) using field in-field technique for patients of post-lumpectomy. Materials and methods: Radiation dose was 2.66 Gy/ fraction, and the total was 42.56 Gy/16 fractions over 3.1 weeks. Radiation field was whole breast using field in-field technique. Eligibility criteria were 1) Invasive carcinoma, DCIS, 2) 20-year old and more 3) post-lumpectomy 4) PS 0-2, and 4) written informed consent. The primary endpoint was adverse effect, and the secondary endpoints were in-breast recurrence, overall recurrence, overall survival, and cosmesis.
Results: Between June 2012 to April 2015, 29 patients registered in the study. Median age was 47-year old (ranged: 34 - 67-year). Histopathology were invasive carcinoma 25 pts, and DCIS 4 pts. Median follow-up was 14-month (ranged: 1 - 35-month). Acute dermatitis occurred all pts with grade 1, but no late adverse effect occurred. No recurrence developed.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Insufficiency Fractures After Pelvic Radiation Therapy for Uterine Cervical Cancer: An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of the Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG).2012
Author(s)
Tokumaru S, Toita T, Oguchi M, Ohno T, Kato S, Niibe Y, Kazumoto T, Kodaira T, Kataoka M, Shikama N, Kenjo M, Yamauchi C, Suzuki O, Sakurai H, Teshima T, Kagami Y, Nakano T, Hiraoka M, Mitsuhashi N, Kudo S.
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 84
Issue: 2
Pages: 195-200
DOI
Related Report
Peer Reviewed
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[Presentation] T1-2N0M0声門癌の加速照射と標準分割照射の第III相試験(JCOG0701) 早期安全性データ2014
Author(s)
斉藤 吉弘(日本臨床腫瘍研究グループ 放射線治療グループ), 古平 毅, 鹿間 直人, 石倉 聡, 平岡 真寛, 中村 健一, 水澤 純基, 松本 康男, 小西 浩司, 伊藤 芳紀, 秋元 哲夫, 中田 健生, 利安 隆史, 西村 恭昌, 加賀美 芳和
Organizer
日本癌治療学会
Place of Presentation
神奈川県
Year and Date
2014-08-28 – 2014-08-30
Related Report
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[Presentation] 乳房温存手術症例に対する腋窩マネジメントの検討と報告2014
Author(s)
橋本 梨佳子, 中村 清吾, 渡辺 知映, 桑山 隆志, 吉村 亮一, 広田 由子, 榎戸 克年, 沢田 晃暢, 加賀美 芳和, 明石 定子, 中島 恵, 金田 陽子, 池田 紫, 高丸 智子, 吉田 玲子, 大山 宗士, 森 美樹
Organizer
日本乳癌学会
Place of Presentation
大阪府
Year and Date
2014-07-10 – 2014-07-12
Related Report
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