Analysis of Notch signaling pathway from the point of pathological and immunohistochemical view - application in the treatment of inflammatory vascular disease
| Project/Area Number |
24591872
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NARITA Hiroshi 名古屋大学, 医学部附属病院, 助教 (00528739)
YAMAMOTO Kiyohito 名古屋大学, 医学(系)研究科(研究院), 准教授 (10298359)
KOMORI Kimihiro 名古屋大学, 医学(系)研究科(研究院), 教授 (40225587)
坂野 比呂志 名古屋大学, 医学部附属病院, 助教 (80584721)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | バージャー病 / 炎症性血管疾患 / 免疫組織化学 / 病理学 / Notch経路 / Notch signal / Notch pathway / 炎症性浸潤細胞 / Notchシグナル / 閉塞性動脈硬化症 |
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| Outline of Final Research Achievements |
Under pathological conditions, Notch signal pathway is involved in the inflammatory process in arteriosclerosis, atherosclerosis and angiogenesis under ischemic conditions. From the point of this process, arteries affected Buerger's disease based on Shionoya's criteria were analyzed with use of anti CD3, CD4 antibodies to evaluate the T and B lymphocyte expression and anti-Nocth-1 and 3, anti-Jagged-1, anti-Delta-1 and 4, and anti-Hes-1 antibodies to examine Notch signal pathway, pathological and immunohistochemically. The distribution of CD3 and 4 is recognized in both the organized thrombus and intima, significantly. Notch-1 and 3 were expressed at the inflammatory infiltrating cells in the thrombus. Jagged-1 and 4, Delta-1 and 4, Hes-1 and 2 were expressed at smooth muscle cells in the media, endothelial cells at vasa vasorum, and inflammatory infiltrating cells in the thrombus. Notch signal pathway could be related the mechanism of Buerger's diseased arteries.
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Report
(4 results)
Research Products
(34 results)
