Innovation with living donor liver transplantation by introducing MSCs for small-for-size graft
Project/Area Number |
24591878
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Kyoto University |
Principal Investigator |
OGAWA Kohei 京都大学, 医学(系)研究科(研究院), 助教 (10359789)
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Co-Investigator(Kenkyū-buntansha) |
上本 伸二 京都大学, 医学(系)研究科(研究院), 教授 (40252449)
寺谷 工 自治医科大学, 医学部, 講師 (70373404)
藤本 康弘 京都大学, 医学(系)研究科(研究院), 助教 (80335281)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 間葉系幹細胞 / 肝移植 / 部分肝移植 / 肝再生 / 臓器保存 / 間葉系肝細胞 |
Outline of Final Research Achievements |
We have shown that the "MSCs are effective for ameliorating liver ischemia-reperfusion injury after hepatectomy", "MSCs are effective in improving recipient survival after prolonged preservation of graft." Based on these data, we evaluated the effect of MSCs with prolonged preservation of partial graft mimicking clinical cadaveric split liver transplantation. However, we could not show the benefit in terms of recipient survival. As histology of the liver showed necrosis and AST and ALT are elevated with MSCs group, MSCs may have detrimental effect such as thrombus formation secondary to cell aggregation. Conditioned medium from MSC culture would be evaluated hereafter.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] How to successfully resect 70 % of the liver in pigs to model an extended hepatectomy with an insufficient remnant or liver transplantation with a small-for-size graft.2014
Author(s)
Hori T, Yagi S, Okamua Y, Iida T, Ogawa K, Tanaka H, Kageyama S, Hirao H, Hata T, Kirino I, Nagai K, Kubora T, Jobara K, Endo K, Uemoto S.
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Journal Title
Surg Today.
Volume: 44
Issue: 11
Pages: 2201-7
DOI
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Assessment of four methodologies (microparticle enzyme immunoassay, chemiluminescent enzyme immunoassay, affinity column-mediated immunoassay, and flow injection assay-tandem mass spectrometry) for measuring tacrolimus blood concentration in Japanese liver transplant recipients.2014
Author(s)
Hashi S, Masuda S, Kikuchi M, Uesugi M, Yano I, Omura T, Yonezawa A, Fujimoto Y, Ogawa K, Kaido T, Uemoto S, Matsubara K.
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Journal Title
Transplant Proc.
Volume: 46
Issue: 3
Pages: 758-760
DOI
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[Presentation] 肝移植モデルにおける幹細胞移植の導入 マージナルグラフトの克服に向けて2013
Author(s)
藤本, 康弘 寺谷, 工 趙, 向東 土井, 淳司 政野, 裕紀 濱口, 雄平 吉村, 美緒 小川, 晃平 海道, 利実 小林, 英司 上本, 伸二
Organizer
第113回日本外科学会定期学術集会
Place of Presentation
福岡国際会議場(福岡)
Related Report
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