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Immunosuppression system by HLA-F - the development of the eliminating system of allo-reactive T cells except for regulatory T cells

Research Project

Project/Area Number 24591886
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionNara Medical University

Principal Investigator

OUJI-SAGESHIMA Noriko  奈良県立医科大学, 医学部, 助教 (30398432)

Co-Investigator(Kenkyū-buntansha) ISHITANI Akiko  奈良県立医科大学, 医学部, 非常勤講師 (40112544)
Co-Investigator(Renkei-kenkyūsha) ICHINOHE Tatsuo  広島大学, 医学部, 教授 (80314219)
TAKAHARA Shiro  大阪大学, 医学(系)研究科(研究院), 寄付講座教授 (70179547)
UEMOTO Shinji  京都大学, 医学(系)研究科(研究院), 教授 (40252449)
YOSHIDA Katsunori  奈良県立医科大学, 医学部, 教授 (50192422)
MORII Takeshi  奈良県立医科大学, 医学部, 講師 (70268451)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords移植外科学 / HLA-F / 制御性T細胞 / 移植 / 拒絶反応 / 非古典的HLAクラスI / HLA-F
Outline of Final Research Achievements

HLA-F is expressed on the cell surface of activated immune cells except for regulatory T cells. We considered that HLA-F expressing immune cells except for regulatory T cells associated with rejection. To aim the establishment of new immunosuppression system by elimination of HLA-F positive cells, we analyzed the expression of HLA-F on peripheral lymphocyte from patients who received transplantation.
We analyzed 1538 samples from 265 patients who received transplantation including 99 liver transplantation, 114 kidney transplantation and 52 stem cell transplantation. We detected HLA-F positive cells on peripheral lymphocyte from patients who received transplantation, although the HLA-F expression did not associate with rejection. Additionally, we detected HLA-F expression on steady-state B cells. We concluded that it was difficult to establish the new immunosuppression system using by HLA-F expression.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2014 2013 2012

All Presentation (6 results)

  • [Presentation] 可溶性HLA-G抗原検出法の確立2014

    • Author(s)
      王寺(下嶋)典子、赤崎正佳、Geraghty DE、喜多英二、石谷昭子、羽竹勝彦、伊藤利洋
    • Organizer
      第29回日本生殖免疫学会総会
    • Place of Presentation
      伊藤国際学術研究センター、東京都文京区
    • Year and Date
      2014-12-13 – 2014-12-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Establishment of the detection system of soluble HLA-G in body fluids2014

    • Author(s)
      Noriko OUJI-SAGESHIMA , Akiko ISHITANI, Daniel E GERAGHTY, Toshihiro ITO
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館、京都府京都市
    • Year and Date
      2014-12-10 – 2014-12-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 体液中の可溶性HLA-G抗原検出法の確立2014

    • Author(s)
      王寺(下嶋)典子、中西真理、貝森淳哉、市丸直嗣、吉澤淳、長谷川淳、米田龍生、森井武志、吉田克法、一戸辰夫、高原史郎、上本伸二、赤崎正佳、Geraghty DE、伊藤利洋、石谷昭子、喜多英二、羽竹勝彦
    • Organizer
      第23回日本組織適合性学会大会
    • Place of Presentation
      長崎大学熱帯医学研究所、長崎県長崎市
    • Year and Date
      2014-09-13 – 2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] The alternative expression patterns and conformational forms of HLA-F.2013

    • Author(s)
      Sageshima N., Lee N., Ishitani A., Geraghty DE.,
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Research-status Report
  • [Presentation] 免疫細胞上のHLA-Fの多様な発現様式2013

    • Author(s)
      下嶋典子、Ni Lee、勇井克也、中西真理、貝森淳哉、矢澤浩治、吉澤淳、長谷川淳、米田龍生、森井武志、吉田克法、一戸辰夫、高原史郎、上本伸二、喜多英二、羽竹勝彦、Geraghty DE、石谷昭子
    • Organizer
      第22回日本組織適合性学会
    • Place of Presentation
      コラッセふくしま
    • Related Report
      2013 Research-status Report
  • [Presentation] 移植患者末梢血リンパ球におけるHLA-G、HLA-Fの発現2012

    • Author(s)
      下嶋典子、勇井克也、貝森淳哉、矢澤浩治、吉澤淳、一戸辰夫、森井武志、長谷川淳、米田龍生、高原史郎、上本伸二、吉田克法、羽竹勝彦、喜多英二、Geraghty DE、石谷昭子
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      明治大学駿河台キャンパス アカデミーコモン・リバティタワー
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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