| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Decreased phagocytic activity against apoptotic cells is known as a cause of surgical stress-induced exaggerated postoperative inflammatory responses, which could result in the occurrence of postoperative complications (POCs). We investigated the associations between blood levels of milk fat globule-EGF factor VIII (MFG-E8) and lysophosphatidylcholine (LPC), which play a role for phagocytosis of apoptotic cells, and exaggerated postoperative inflammatory responses followed by POCs in patients with gastrointestinal surgery. Significant decreases of LPC levels were observed after surgery and the decrease is dependent on the magnitude of surgical stress. The decrease of LPC is inversely correlated with IL-6 levels. Patients with POCs showed a greater reduction of LPC than patients without POCs. The postoperative LPC levels have predictive impact for POCs. The postoperative decrease of LPC could be a mechanism of exaggerated postoperative inflammatory responses and POCs.
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