| Project/Area Number |
24591902
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Osaka University |
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Principal Investigator |
TANIYAMA Yoshiaki 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 (60372611)
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| Co-Investigator(Kenkyū-buntansha) |
MORISHITA Ryuichi 大阪大学, 大学院医学系研究科, 寄附講座教授 (40291439)
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| Co-Investigator(Renkei-kenkyūsha) |
NOGUCHI Sinzaburo 大阪大学, 大学院医学系研究科, 教授 (10303942)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | トリプルネガティブ乳癌 / 癌転移 / 中和抗体 / Wnt シグナル / 肺転移 / ペリオスチン / 乳癌 / 転移 / 癌幹細胞 / 悪性黒色腫 |
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| Outline of Final Research Achievements |
Breast cancer occurs the most frequently in women of the world. The breast cancer without the receptors of progesterone, estrogen and HER2 is called triple negative breast cancer (TNBC), and we don't have no drugs for it. We confirmed that TNBC secretes periostin (PN) protein excessively, and made PN neutralizing antibody originally. Pn antibody inhibited the growth of primary focus and metastasis for lung. I found that PN protein combines with Wnt and promoted Wnt signal as a mechanism of breast cancer increasing by PN.
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