The identification of functional role of CD44 in redox status and the application to therapeutic strategy in cancer
| Project/Area Number | 24591912 |
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWATSUKI Masaaki 熊本大学, 医学部附属病院, 非常勤診療医師 (50452777)
BEPPU Toru 熊本大学, 医学部附属病院, 特任教授 (70301372)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed(Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost : ¥3,900,000、Indirect Cost : ¥1,170,000)
Fiscal Year 2014 : ¥1,560,000 (Direct Cost : ¥1,200,000、Indirect Cost : ¥360,000)
Fiscal Year 2013 : ¥1,820,000 (Direct Cost : ¥1,400,000、Indirect Cost : ¥420,000)
Fiscal Year 2012 : ¥1,690,000 (Direct Cost : ¥1,300,000、Indirect Cost : ¥390,000)
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| Keywords | CD44 / xCT / microRNA / CTC / 消化器癌 / 癌幹細胞 / 活性酸素 / 治療抵抗性 |
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| Outline of Final Research Achievements |
CD44v-xCT plays a key role in the maintenance of undifferentiated head and neck squamous cell carcinoma (HNSCC) tumors rather than differentiated-type HNSCC tumors, and confers the ability of evasion from oxidative stress in several types of cancer and thereby promotes the lung metastasis. Furthermore, microRNA qRT-PCR array analysis identified miR-328 as one of the microRNAs targeting CD44 in gastric cancer. miR-328-CD44 signaling mediated by chronic inflammation is implicated in gastric cancer development and progression.
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Report
(4results)
Research Products
(16results)
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[Journal Article] Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation2014
Author(s)
Ishimoto T, Sugihara H, Watanabe M, Sawayama H, Iwatsuki M, Baba Y, Okabe H, Hidaka K, Yokoyama N, Miyake K, Yoshikawa M, Nagano O, Komohara Y, Takeya M, Saya H, Baba H.
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Journal Title
Carcinogenesis
Volume : 35(5)
Pages : 1003-11
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cystine/glutamic acid transporter (xCT) is a novel marker for predicting poor survival in patients with hepatocellular carcinoma2013
Author(s)
Kinoshita H, Okabe H, Beppu T, Chikamoto A, Hayashi H, Imai K, Mima K, Nakagawa S, Ishimoto T, Miyake K, Yokoyama N, Ishiko T, Baba H.
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Journal Title
Oncol Rep
Volume : 29
Pages : 685-689
DOI
Related Report
Peer Reviewed
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[Journal Article] xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma2013
Author(s)
Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O
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Journal Title
Cancer Res
Volume : 73(6)
Pages : 1855-1866
DOI
Related Report
Peer Reviewed
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[Journal Article] Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.2012
Author(s)
Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T,Mogushi K, Tanaka H, Osawa T, Kanki Y, et al
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Journal Title
Nature Communications
Volume : 6;3
Pages : 883-883
DOI
Related Report
Peer Reviewed
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