| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Previously we found, collagen Type V α3(following α3(V)) is shown to have anti-fibrosis and tissue adhesion inhibition. Their included in an amnion slightly. The aim of this study that, purify from amnion and is to develop novel anti-adhesion devices by utilizing α3(V). However we have any difficulties for extraction of entire α3(V) molecule with kept functions. It was shown that partial α3(V) functional domain is used for more realistic approach in this aims. On the other hand, we have isolated and characterized by muscular fasciae derived cells that, expressed α3(V) and contributed anti-adhesion effect. Additionally, we construct several prototype devices with collagen base for tissue regeneration, in this study.
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