Collagen Type V a3 chain applied new therapy for their anti-organ adhesion activity
| Project/Area Number |
24591918
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Yutaka 東海大学, 医学部, 教授 (80193548)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 癒着防止 / V型コラーゲンα３鎖 / 組織線維化 / V型コラーゲンα3鎖 / 線維化の防止 / コラーゲンの集束 / V型コラーゲンa3鎖 |
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| Outline of Final Research Achievements |
Previously we found, collagen Type V α3(following α3(V)) is shown to have anti-fibrosis and tissue adhesion inhibition. Their included in an amnion slightly. The aim of this study that, purify from amnion and is to develop novel anti-adhesion devices by utilizing α3(V). However we have any difficulties for extraction of entire α3(V) molecule with kept functions. It was shown that partial α3(V) functional domain is used for more realistic approach in this aims. On the other hand, we have isolated and characterized by muscular fasciae derived cells that, expressed α3(V) and contributed anti-adhesion effect. Additionally, we construct several prototype devices with collagen base for tissue regeneration, in this study.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Epiplakin modifies the motility of the HeLa cells and accumulates at the outer surfaces of 3-D cell clusters.2013
Author(s)
Shimada H, Nambu-Niibori A, Wilson-Morifuji M, Mizuguchi S, Araki N, Sumiyoshi H, Sato M, Mezaki Y, Senoo H, Ishikawa K, Hatano Y, Okamoto O, Fujiwara S
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Journal Title
J Dermatol
Volume: 40
Issue: 4
Pages: 249-58
DOI
Related Report
Peer Reviewed
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[Presentation] Identification of a Novel Bone Marrow Cell-derived Factor That Suppresses Fibrogenesis and Accelerates Regeneration of Murine Fibrotic Liver2013
Author(s)
Hideaki Sumiyoshi, Hiroshi Fukumitsu, Reiichi Higashiyama, Sachie Nakao, Kaori Minakawa, Minako Sueoka, Hiromi Chikada, Akihide Kamiya, Kiyoshi Higashi, Koichi Saito, Yutaka Inagaki.
Organizer
The 20th Annual meeting of the Japanese society for the research of hepatic cells
Place of Presentation
グランキューブ大阪(大阪）
Related Report
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