| Project/Area Number |
24591950
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Japanese Foundation for Cancer Research (2013-2015)
Kumamoto University (2012) |
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Principal Investigator |
Msayuki Watanabe 公益財団法人がん研究会, その他部局等, その他 (80254639)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIMOTO Takatsugu 熊本大学, 大学院生命科学研究部, 特任助教 (00594889)
BABA Yoshifumi 熊本大学, 医学部附属病院, 助教 (20599708)
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| Research Collaborator |
KURASHIGE Junji
TANAKA Yohei
SHIGAKI Hironobu
ETO Kojiro
HARADA Kazuto
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 食道癌 / 化学療法感受性 / 個別化治療 / mircoRNA / FBXW7 / Ribophorin II / microRNA-223 / microRNA-21 / 術前化学療法 / 治療感受性 / マイクロＲＮＡ / miR-21 / miR-30e* / miR-223 / がん幹細胞 / 食道扁平上皮癌 / microRNA / DCF療法 / CD44 / Bmi1 / TAM / miR-328 / exosome / RNP2 |
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| Outline of Final Research Achievements |
The aim of this study was to evaluate the possibility of individualized treatment strategy for esophageal cancer based on the expression of microRNAs in pretreatment biopsy specimens. We revealed that miR-223, which influenced sensitivity to chemotherapeutic agents through regulating the expression of FBXW7, was overexpressed in esophageal cancer tissues compared to normal esophageal epithelium. We also demonstrated that the expression levels of Ribophorin II (RPN2) can be a predictor of sensitivity to Docetaxel. In addition, we found the levels of serum miR-21 or exosomal miR-21 were higher in esophageal cancer patients than in controls and they can be biomarkers for chemosensitivity.
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