Individualized treatment strategy for esophageal cancer based on the expression of microRNAs in preoperative biopsy specimens.
Project/Area Number |
24591950
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Japanese Foundation for Cancer Research (2013-2015) Kumamoto University (2012) |
Principal Investigator |
Msayuki Watanabe 公益財団法人がん研究会, その他部局等, その他 (80254639)
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Co-Investigator(Kenkyū-buntansha) |
ISHIMOTO Takatsugu 熊本大学, 大学院生命科学研究部, 特任助教 (00594889)
BABA Yoshifumi 熊本大学, 医学部附属病院, 助教 (20599708)
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Research Collaborator |
KURASHIGE Junji
TANAKA Yohei
SHIGAKI Hironobu
ETO Kojiro
HARADA Kazuto
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 食道癌 / 化学療法感受性 / 個別化治療 / mircoRNA / FBXW7 / Ribophorin II / microRNA-223 / microRNA-21 / 術前化学療法 / 治療感受性 / マイクロRNA / miR-21 / miR-30e* / miR-223 / がん幹細胞 / 食道扁平上皮癌 / microRNA / DCF療法 / CD44 / Bmi1 / TAM / miR-328 / exosome / RNP2 |
Outline of Final Research Achievements |
The aim of this study was to evaluate the possibility of individualized treatment strategy for esophageal cancer based on the expression of microRNAs in pretreatment biopsy specimens. We revealed that miR-223, which influenced sensitivity to chemotherapeutic agents through regulating the expression of FBXW7, was overexpressed in esophageal cancer tissues compared to normal esophageal epithelium. We also demonstrated that the expression levels of Ribophorin II (RPN2) can be a predictor of sensitivity to Docetaxel. In addition, we found the levels of serum miR-21 or exosomal miR-21 were higher in esophageal cancer patients than in controls and they can be biomarkers for chemosensitivity.
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Report
(5 results)
Research Products
(36 results)
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[Journal Article] The sensitivity of gastric cancer to trastuzumab is regulated by the miR-223/FBXW7 pathway.2015
Author(s)
Eto K, Iwatsuki M, Watanabe M, Ishimoto T, Ida S, Imamura Y, Iwagami S, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Baba H:
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Journal Title
Int J Cancer
Volume: 136
Pages: 1537-1545
DOI
Related Report
Peer Reviewed
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[Journal Article] Chronic inflammation with helicobactor pylori-infectionis implicated in CD44 overexpression through miR-328 suppression in the gastric mucosa.2015
Author(s)
Ishimoto T, Izumi D, Watanabe M, Yoshida N, Hidaka K, Miyake K, Sugihara H, Sawayama H, ImamuraY, Iwatsuki M, Iwagami S, Baba Y, Horlad H, Komohara Y, Takeya M, Baba H
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Journal Title
J Gastroenterol
Volume: 50
Pages: 751-757
DOI
Related Report
Peer Reviewed
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[Journal Article] Suppressor microRNA-145 is epigenetically regulated by promoter hypermethylation in esophageal squamous cell carcinoma2015
Author(s)
Harada K, Baba Y, Ishimoto T, Kosumi K, Tokunaga R, Izumi D, Ohuchi M, Nakamura K, Kiyozumi Y, Kurashige J, Iwagami S. Miyamoto Y, Sakamoto Y, Yoahida N, Watanabe M, Baba H
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Journal Title
Anticancer Res
Volume: 35
Pages: 4617-4624
Related Report
Peer Reviewed
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[Journal Article] The microRNA-21/PTEN pathway regulates the sensitivity of HER2-positive gastric cancer cells to trastuzumab.2014
Author(s)
Eto K, Iwatsuki M, Watanabe M, Ida S, Ishimoto T, Iwagami S, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Baba H
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Journal Title
Ann Surg Oncol
Volume: 21
Pages: 343-350
DOI
Related Report
Peer Reviewed
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[Journal Article] Changes in Body Composition Secondary to Neoadjuvant Chemotherapy for Advanced Esophageal Cancer are Related to the Occurrence of Postoperative Complications After Esophagectomy.2014
Author(s)
Ida S, Watanabe M, Karashima R, Imamura Y, Ishimoto T, Baba Y, Iwagami S, Sakamoto Y, Miyamoto Y, Yoshida N, Baba H
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Journal Title
Ann Surg Oncol
Volume: 21
Pages: 3675-3679
DOI
Related Report
Peer Reviewed
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[Journal Article] Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation2014
Author(s)
Ishimoto T, Sugihara H, Watanabe M, Sawayama H, Iwatsuki M, Baba Y, Okabe H, Hidaka K, Yokoyama N, Miyake K, Yoshikawa M, Nagano O, Komohara Y, Takeya M, Saya H, Baba H
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Journal Title
Carcinogenesis
Volume: 35
Pages: 1003-1011
DOI
Related Report
Peer Reviewed
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[Journal Article] Macropharge-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation2014
Author(s)
123 Ishimoto T., Sugihara H., Watanabe M., Sawayama H., Iwatsuki M., Baba Y., Okabe H., Hidaka K., Yokoyama N., Miyake K., Yoshikawa M., Nagano O., Komohara Y., Takeya M., Saya H., Baba H
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Journal Title
Carcinogenesis
Volume: 35
Pages: 1003-1011
DOI
Related Report
Peer Reviewed
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[Journal Article] The mirroRNA-21/PTEN pathway regulates the sensitivity og HER2-positive gastric cancer to trastuzumab2014
Author(s)
112 Eto K.,Iwatsuki M., Watanabe M., Ida S., Ishimoto T., Iwagami S., Baba Y., Sakamoto Y., Miyamoto Y., Yoshida N., Baba H
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Journal Title
Ann Surg Oncol
Volume: 21
Pages: 343-350
DOI
Related Report
Peer Reviewed
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[Journal Article] Influence of preoperative docetaxel, cisplatin, and 5-fluorouracil on the incidence of complication after esophagectomy for resectable advanced esophageal cancer2014
Author(s)
108 Yoshida N., Watanabe M., Baba Y., Ishimoto T., Iwagami S., Sakamoto Y., Miyamoto Y., Karashima R., Baba H
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Journal Title
Dis Esophagus
Volume: 27
Pages: 374-379
DOI
Related Report
Peer Reviewed
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[Presentation] Novel discovery of miR-30e* regulating Bmi1 expression mediated by tumor-associated macrophages in gastric cancer.2013
Author(s)
Hidetaka Sugihara、Takatsugu Ishimoto, Daisuke Izumi, Hiroshi Sawayama, Yu Imamura, Satoshi Ida, Shiro Iwagami,Yoshifumi Baba,Yasuo Sakamoto,Yuji Miyamoto,Naoya Yoshida,Hideo Baba
Organizer
The 4th JCA-AACR
Place of Presentation
千葉
Year and Date
20131216-20131218
Related Report
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