| Project/Area Number |
24591952
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUKAMOTO Yoshiyuki 大分大学, 医学部, 助教 (00433053)
SHIBATA Tomotaka 大分大学, 医学部, 助教 (20566905)
FUMOTO Shoichi 大分大学, 医学部, 客員研究員 (00532631)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | テイラード医療 / 効果予測システム / マイクロアレイ / 抗癌剤 / 食道癌 |
|---|
| Outline of Final Research Achievements |
A novel statistical analysis, a two-dimensional mixed normal model, provided 3 (CARD8, TMUB2, and EMX2) and 6 candidates (C10orf97, CCDC90B, IFITM1, TARBP1, TTYH2, and MARK1) respectively for 5-FU and CDDP, as novel sensitivity marker genes in esophageal cancer. And we developed highly predictive formulae in vitro and in vivo using expression data of a set of the all selected marker genes.
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