Identification of novel drug-response determinants in esophageal squamous cell carcinoma
| Project/Area Number |
24591952
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUKAMOTO Yoshiyuki 大分大学, 医学部, 助教 (00433053)
SHIBATA Tomotaka 大分大学, 医学部, 助教 (20566905)
FUMOTO Shoichi 大分大学, 医学部, 客員研究員 (00532631)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | テイラード医療 / 効果予測システム / マイクロアレイ / 抗癌剤 / 食道癌 |
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| Outline of Final Research Achievements |
A novel statistical analysis, a two-dimensional mixed normal model, provided 3 (CARD8, TMUB2, and EMX2) and 6 candidates (C10orf97, CCDC90B, IFITM1, TARBP1, TTYH2, and MARK1) respectively for 5-FU and CDDP, as novel sensitivity marker genes in esophageal cancer. And we developed highly predictive formulae in vitro and in vivo using expression data of a set of the all selected marker genes.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] TSPAN8, identified by Escherichia coli ampicillin secretion trap, is associated with cell growth and invasion in gastric cancer2015
Author(s)
Katsuhiro Anami, Naohide Oue, Tsuyoshi Noguchi, Naoya Sakamoto, Kazuhiro Sentani, Tetsutaro Hayashi, Yutaka Naito, Htoo Zarni Oo, Wataru Yasui
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Journal Title
Gastric Cancer
Volume: ahead of print
Issue: 2
Pages: 370-380
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice.2013
Author(s)
Nakano S, Ikebe E, Tsukamoto Y, Wang Y, Matsumoto T, Mitsui T, Yahiro T, Inoue K, Kawazato H, Yasuda A, Ito K, Yokoyama S, Takahashi N, Hori M, Shimada T, Moriyama M, Kubota T, Ono K, Fujibuchi W, Jeang KT, Iha H, Nishizono A.
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Journal Title
PLoS One
Volume: 8(9)
Issue: 9
Pages: e73205-e73205
DOI
Related Report
Peer Reviewed
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