Development of cancer vaccine therapy by targeting cell cycle of cancer stem cell

• Project/Area Number: 24591981
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: MATSUDA Kenji 和歌山県立医科大学, 医学部, 講師 (30398458)
• Co-Investigator(Kenkyū-buntansha): YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190) ; HOTTA Tsukasa 和歌山県立医科大学, 医学部, 教授 (50244744) ; KATSUDA Masahiro 和歌山県立医科大学, 医学部, 助教 (50464673) ; IWAHASHI Makoto 和歌山県立医科大学, 医学部, 博士研究員 (70244738) ; YOKOYAMA Shozo 和歌山県立医科大学, 医学部, 講師 (90398462)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: PML / peptide / ペプチド / 亜ヒ酸

Outline of Final Research Achievements

We have targeted PML which reportedly regulate cell cycle. We have expected　that cancer stem cell was thrown out from G0 status by targeting PML and which increases chemosinsitivety. We have assesed the correlation between the expression of PML and chemosensitivity. We have not found out a significant relation up to the present. On the other hand, we have shown the possibility of PML targeted cancer vaccine therapy by using TLR ligand in mouse model.

Research Products

• [Journal Article] 10.Randomized clinical trial of defaecatory function after anterior resection for rectal cancer with high versus low ligation of inferior mesenteric artery (2015)
  • Author(s): Matsuda K, Hotta T, Yokoyama S,Yamaue Y
  • Journal Title: Br J Surg Volume: 102 Issue: 5 Pages: 501-508
  • DOI: 10.1002/bjs.9739
  • Peer Reviewed
• [Journal Article] 9.Clinical characteristics of anastomotic leakage after an anterior resection for rectal cancer by assessing of the International Classification on anastomotic leakage (2015)
  • Author(s): Matsuda K, Hotta T, Yokoyama S,Yamaue H
  • Journal Title: Lanagenbecks Arch Surg Volume: 400 Issue: 2 Pages: 207-212
  • DOI: 10.1007/s00423-015-1272-4
  • Peer Reviewed
• [Journal Article] Guidance for peptide vaccines for the treatment of cancer. (2014)
  • Author(s): Yamaguchi Y, Yamaue H, Okusaka T, Okuno K, Suzuki H, Fujioka T, Otsu A, Ohashi Y, Shimazawa R, Nishio K, Furuse J, Minami H, Tsunoda T, Hayashi Y, Nakamura Y
  • Journal Title: Cancer Science Volume: 105 Issue: 7 Pages: 924-931
  • DOI: 10.1111/cas.12443
  • NAID: 120006986476
  • Peer Reviewed
• [Journal Article] Clinical outcome of up-front surgery in patients with asymptomativ, incurable synchronous peritoneal carcinomatosis (2013)
  • Author(s): Matsuda K
  • Journal Title: Surg Today Volume: 43 Issue: 9 Pages: 984-989
  • DOI: 10.1007/s00595-012-0348-9
  • Peer Reviewed
• [Journal Article] Angiosarcoma involving colon and bone successfully responded to paclitaxel and zoledronate: case report (2013)
  • Author(s): Matsuda K
  • Journal Title: Clin J Gastroenterology Volume: 6 Issue: 1 Pages: 20-24
  • DOI: 10.1007/s12328-012-0348-8
  • Peer Reviewed
• [Journal Article] Clinical impact of a macroscopically complete resection of colorectal cancer with peritoneal carcinomatosis (2012)
  • Author(s): Matsuda K
  • Journal Title: Surgery Volume: 151 Issue: 2 Pages: 238-244
  • DOI: 10.1016/j.surg.2010.10.018
  • Peer Reviewed
• [Presentation] 標準療法不能食道癌に対するHLA-A24またはHLA-A02拘束性マルチエピトープペプチドを用いたカクテルワクチン療法-第I/II相臨床試験 (2014)
  • Author(s): 勝田将裕、山上裕機
  • Organizer: 第35回癌免疫外科研究会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-23
• [Presentation] 大腸癌腹膜播種に対する切除の現状と限界 (2014)
  • Author(s): 松田健司、堀田司、横山省三、山上裕機
  • Organizer: 第114回日本外科学会
  • Place of Presentation: 京都
  • Year and Date: 2014-04-03 – 2014-04-05
• [Presentation] 切除可能な大腸癌肝転移に対する術前化学療法の検討 (2012)
  • Author(s): 松田健司
  • Organizer: 第67回日本大腸肛門病学会
  • Place of Presentation: 福岡
• [Presentation] 切除不能な腹膜播種を伴う大腸癌の原発巣切除の検討 (2012)
  • Author(s): 松田健司
  • Organizer: 第67回日本消化器外科学会
  • Place of Presentation: 富山
• [Presentation] 高度進行肝転移に対する周術期化学療法の検討
  • Author(s): 松田健司
  • Organizer: 第113回日本外科学会
  • Place of Presentation: 福岡