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Cancer stem cell in colorectal liver metastasis

Research Project

Project/Area Number 24592009
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionYokohama City University

Principal Investigator

TANAKA Kuniya  横浜市立大学, 医学(系)研究科(研究院), 客員教授 (10295503)

Co-Investigator(Kenkyū-buntansha) HIRANO Hisashi  横浜市立大学, 生命科学研究科, 特任教授 (00275075)
HIROSHIMA Yukihiko  横浜市立大学, 医学研究科, 客員研究員 (60718021)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords癌幹細胞 / 大腸癌肝転移 / CD133 / CD44 / E cadherin / 転移性肝癌 / 大腸癌 / 肝転移 / CD13
Outline of Final Research Achievements

The CD44-positive rate in primary lesions and L-Mets was 41.4 and 58.7 %, respectively. There was no correlation of CD44 expression between primary lesions and L-Mets (r = 0.250, p = 0.071). The CD133-positive rate in primary lesions and L-Mets was 53.6 and 44.6 %, respectively. There was no correlation of CD133 expression between primary lesions and L-Mets (r = 0.219, p = 0.135). In the CD133-negative group, the MIB-1 index was significantly higher than in the CD133-positive group (61.6 vs. 46.3 %, p = 0.003), and E-cadherin expression was significantly lower in the CD133-negative group compared with the CD133-positive group (29.3 vs. 46.8 %, p = 0.001). Absence of CD133 expression in L-Mets correlated with poor overall survival (p = 0.006), and multivariate regression analysis showed that it was an independent marker for poor survival (hazard ratio 0.320, p = 0.0016).

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2015 2014 2013 Other

All Journal Article (12 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 12 results,  Acknowledgement Compliant: 7 results,  Open Access: 4 results) Presentation (9 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] ALPPS: Short-term Outcome and Functional Changes in the Future Liver Remnant.2015

    • Author(s)
      Tanaka K, Endo I.
    • Journal Title

      Ann Surg.

      Volume: 262 Issue: 2 Pages: e88-e89

    • DOI

      10.1097/sla.0000000000000665

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Low infiltration of peritumoral regulatory T cells predicts worse outcome following resection of colorectal liver metastases.2015

    • Author(s)
      Nakagawa K, Tanaka K, Homma Y, Nojiri K, Kumamoto T, Takeda K, Endo I.
    • Journal Title

      Low infiltration of peritumoral regulatory T cells predicts worse outcome following resection of colorectal liver metastases.

      Volume: 22 Issue: 1 Pages: 180-186

    • DOI

      10.1245/s10434-014-3974-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model.2015

    • Author(s)
      Murakami T, Hiroshima Y, Zhao M, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
    • Journal Title

      Oncotarget

      Volume: 6 Issue: 39 Pages: 41856-41862

    • DOI

      10.18632/oncotarget.6170

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fluorescence-Guided Surgery of Liver Metastasis in Orthotopic Nude-Mouse Models.2015

    • Author(s)
      Murakami T, Hiroshima Y, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 10 Pages: e0138752-e0138752

    • DOI

      10.1371/journal.pone.0138752

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Therapeutic efficacy of tumor-targeting Salmonella typhimurium A1-R on human colorectal cancer liver metastasis in orthotopic nude-mouse models.2015

    • Author(s)
      Murakami T, Hiroshima Y, Zhao M, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
    • Journal Title

      Oncotarget

      Volume: 6 Issue: 31 Pages: 31368-31377

    • DOI

      10.18632/oncotarget.5187

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Tumor-Targeting Salmonella typhimurium A1-R Arrests a Chemo-Resistant Patient Soft-Tissue Sarcoma in Nude Mice.2015

    • Author(s)
      Hiroshima Y, Zhao M, Zhang Y, Zhang N, Maawy A, Murakami T, Mii S, Uehara F, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 8 Pages: e0134324-e0134324

    • DOI

      10.1371/journal.pone.0134324

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models.2014

    • Author(s)
      Hiroshima Y, Zhang Y, Murakami T, Maawy A, Miwa S, Yamamoto M, Yano S, Sato S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Zhao M, Hoffman RM.
    • Journal Title

      Oncotarget

      Volume: 15;5(23) Pages: 12346-57

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Efficacy of Salmonella typhimurium A1-R Versus Chemotherapy on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX).2014

    • Author(s)
      Hiroshima Y, Zhao M, Maawy A, Zhang Y, Katz MH, Fleming JB, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
    • Journal Title

      J Cell Biochem

      Volume: 115(7) Issue: 7 Pages: 1254-61

    • DOI

      10.1002/jcb.24769

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful fluorescence-guided surgery on human colon cancer patient-derived orthotopic xenograft mouse models using a fluorophore-conjugated anti-CEA antibody and a portable imaging system.2014

    • Author(s)
      Hiroshima Y, Maawy A, Metildi CA, Zhang Y, Uehara F, Miwa S, Yano S, Sato S, Murakami T, Momiyama M, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
    • Journal Title

      J Laparoendosc Adv Surg Tech A.

      Volume: 24(4) Issue: 4 Pages: 241-7

    • DOI

      10.1089/lap.2013.0418

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by zoledronic acid.2014

    • Author(s)
      Hiroshima Y, Maawy A, Hassanein MK, Menen R, Momiyama M, Murakami T, Miwa S, Yamamoto M, Uehara F, Yano S, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM.
    • Journal Title

      PLoS One.

      Volume: 12;9(8) Issue: 8 Pages: e103382-e103382

    • DOI

      10.1371/journal.pone.0103382

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fluorescence-guided surgery in combination with UVC irradiation cures metastatic human pancreatic cancer in orthotopic mouse models.2014

    • Author(s)
      Hiroshima Y, Maawy A, Zhang Y, Sato S, Murakami T, Yamamoto M, Uehara F, Miwa S, Yano S, Momiyama M, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
    • Journal Title

      PLoS One.

      Volume: 12;9(6) Issue: 6 Pages: e99977-e99977

    • DOI

      10.1371/journal.pone.0099977

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Patients with CD133-negative colorectal liver metastasis have a poor prognosis after hepatectomy2014

    • Author(s)
      Yamamoto S, Nagashima Y et al
    • Journal Title

      Ann Surg Oncol

      Volume: 21(6) Issue: 6 Pages: 1853-61

    • DOI

      10.1245/s10434-014-3549-1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] The correlation between the change of future liver remnant volume and functional capacity in ALPPS (associating liver partition and portal vein ligation for staged hepatectomy), and establishment of ALPPS model in rats2015

    • Author(s)
      Kawaguchi Daisuke, Yukihiko Hiroshima, Takashi Murakami, Kenichi Matsuo, Chihiro Kosugi, Kiyohiko Syuto, Masashi Momiyama, Itaru Endo, Keiji Koda, Kuniya Tanaka
    • Organizer
      AACR
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Curative fluorescence-guided surgery of pancreatic cancer in combination with UVC irradiation in orthotopic mouse models2015

    • Author(s)
      Yukihiko Hiroshima, Ali Maawy, Yong Zhang, Sho Sato, Takashi Murakami, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
    • Organizer
      AACR
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fluorescence-guided surgery with an anti-CA 19-9-conjugated fluorophore in combination with neoadjuvant chemotherapy inhibits metastatic recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) nude mouse model2015

    • Author(s)
      Yukihiko Hiroshima1, Ali Maawy2, Yong Zhang3, Takashi Murakami4, Masashi Momiyama4, Ryutaro Mori4, Ryusei Matsuyama4, Matthew H. Katz5, Jason B. Fleming5, Takashi Chishima4, Kuniya Tanaka4, Yasushi ichikawa4, Itaru Endo4, Robert M. Hoffman6, Michael Bouvet2.
    • Organizer
      米国癌学会(AACR annual meeting 2015)
    • Place of Presentation
      Philadelphia、米国
    • Year and Date
      2015-04-19 – 2015-04-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Efficacy of photo-immunotherapy in combination with surgical resection on a pancreatic cancer patient derived orthotopic xenograft (PDOX)2015

    • Author(s)
      Yukihiko Hiroshima1, Ali Maawy2, Takashi Murakami1, Nzola De Magalhães2, Daisuke Kawaguchi3, Kenichi Matsuo3, Kuniya Tanaka3, Michael Bouvet2, Robert M. Hoffman2, Itaru Endo1.
    • Organizer
      米国癌学会(AACR annual meeting 2015)
    • Place of Presentation
      Philadelphia、米国
    • Year and Date
      2015-04-19 – 2015-04-22
    • Related Report
      2014 Research-status Report
  • [Presentation] The correlation between the change of future remnant liver volume and functional capacity in ALPPS (associating liver partition and portal vein ligation for staged hepatectomy), and establishment of ALPPS model in rats2015

    • Author(s)
      Daisuke Kawaguchi1, Yukihiko Hiroshima1, Takashi Murakami1, Kenichi Matsuo1, Chihiro Kosugi1, Kiyohiko Syuto1, Akimitsu Yamada2, Itaru Endo2, Keiji Koda1, Kuniya Tanaka1.
    • Organizer
      米国癌学会(AACR annual meeting 2015)
    • Place of Presentation
      Philadelphia、米国
    • Year and Date
      2015-04-19 – 2015-04-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Fluorescence-guided surgery of liver metastasis in orthotopic nude-mouse models2015

    • Author(s)
      Takashi Murakami1, Yukihiko Hiroshima1, Shinji Miwa1, Yano Shuya1, Makoto Toneri1, Mako Yamamoto1, Masashi Momiyama2, Takashi Chishima2, Kuniya Tanaka2, Michael Bouvet1, Satoshi Hasegawa2, Itaru Endo2, Robert M. Hoffman3.
    • Organizer
      米国癌学会(AACR annual meeting 2015)
    • Place of Presentation
      Philadelphia、米国
    • Year and Date
      2015-04-19 – 2015-04-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Curative fluorescence-guided surgery of pancreatic cancer in combination with UVC irradiation in orthotopic mouse models2015

    • Author(s)
      Yukihiko Hiroshima1, Ali Maawy2, Yong Zhang1, Sho Sato3, Takashi Murakami1, Mako Yamamoto1, Fuminari Uehara1, Shinji Miwa1, Shuya Yano1, Masashi Momiyama3, Takashi Chishima3, Kuniya Tanaka3, Michael Bouvet2, Itaru Endo3, Robert M. Hoffman2.
    • Organizer
      米国癌学会(AACR annual meeting 2015)
    • Place of Presentation
      Philadelphia、米国
    • Year and Date
      2015-04-19 – 2015-04-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 大腸癌肝転移巣における癌幹細胞マーカー (CD44,CD133)発現の意義2013

    • Author(s)
      山本晋也
    • Organizer
      日本外科学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸癌肝転移巣におけるCD133発現の意義

    • Author(s)
      山本晋也
    • Organizer
      第33回癌免疫外科研究会
    • Place of Presentation
      新横浜プリンスホテル(神奈川県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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