| Project/Area Number |
24592048
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
MASUDA SHINYA 東北大学, 医学(系)研究科(研究院), 非常勤講師 (30596094)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBUYA Takumi 東北大学, 大学院医学系研究科, 非常勤講師 (10526453)
KAWAMOTO Shunsuke 東北大学, 大学院医学系研究科, 准教授 (20400244)
SAIKI Yoshikatsu 東北大学, 大学院医学系研究科, 教授 (50372298)
YANBE Tomoyuki 東北大学, 加齢医学研究所, 教授 (70241578)
AKIYAMA Masatoshi 東北大学, 病院, 講師 (80526450)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 右心不全 / 人工心筋 / 右心不全モデル / 心臓外科 / 人工心臓 / 補助人工心臓 / 心臓大血管外科学 / 循環器・高血圧 |
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| Outline of Final Research Achievements |
We confirmed a supporting effect in Mock circuit and decided a structure of the device and made a canine right heart failure model by injected ethanol to a free wall of right ventricle. After 2 weeks on injection ethanol, in a canine model, RVSW reduced and a pathological liver congestion was revealed. We carried out an acute experiment for a right heart failure model with a device of artificial myocardium. The device of artificial myocardium led the increase of left ventricular end-diastolic volume. We would improve this device and perform the chronic experiment for effectiveness.
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