New therapy using Bartonella henselae for severe ischemic limb

• Project/Area Number: 24592055
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Gifu University
• Principal Investigator: SHIMABUKURO Katsuya 岐阜大学, 医学部附属病院, 講師 (20362163)
• Co-Investigator(Kenkyū-buntansha): MATSUNO Yukihiro 岐阜大学, 医学部附属病院, 助教 (10542409) ; TAKEMURA Hirofumi 岐阜大学, 大学院医学系研究科, 教授 (20242521)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 重症虚血肢 / 感染 / 血管新生

Outline of Final Research Achievements

Severe ischemic limb model using rat was made an attempt for this study. Femoral artery was clamped at regular time (30-300 minutes) and re-perfused and observed for limb change with pathological tissue. Rat model was died or survived but pathological tissue showed no tissue injury.
We could not make severe ischemic limb model using rat and made an effect in a defined period.