| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Bacterial infection from outer surface of prosthetic vascular graft is a subject of our study. The research was done with the models of contaminated vascular graft to investigate the mechanism of bacterial invasion into prosthetic vascular graft from outer surface. Pseudomonas aeruginosa was selected as the model bacterium for its mobility and ability to thrive in physiological saline. Furthermore, a cross section of the vascular grafts were observed with scanning electron microscopy to confirm the bacterial invasion into vascular grafts. Recently, we perform the experiment to measure the amount of gene of protease from bacteria contacted with gelatin-coated Dacron vascular graft by RT-PCR method. Its pilot study is now ongoing.
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