Proteomic analysis of lung adenocarcinoma with micropapillary component to achieve valuable biomarker
| Project/Area Number |
24592099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Yuichi 北里大学, 医療衛生学部, 教授 (30178793)
JIANG Shi-Xu 北里大学, 医学部, 准教授 (70276153)
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| Research Collaborator |
NAKASHIMA Hiroyasu 北里大学, 医学部, 助教
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肺腺癌 / 微乳頭構造 / ビメンチン / 免疫組織化学染色 / 二次元電気泳動 / 網羅的タンパク発現解析 / Lung adenocarcinoma / Micropapillary pattern / Immunohistochemistry / Vimentin / micropapillary pattern / タンパク / 免疫染色 / 臨床病理学的因子 / micropapiｌlary pattern / 網羅的解析 / 2次元電気泳動 |
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| Outline of Final Research Achievements |
The factors conferrng the increased malignancy on lung adenocarcinoma with micropapillary component (AC-MPC) remain to be elucidated. 2-dimensional gel electrophoresis, several proteins differentially expressed between AC-MPC and conventional adenocarcinoma (CAC); in particular, vimentin, one of the proteins, was most up-regulated in AC-MPC. Immunohistochemistry revealed that vimentin was expressed in most of MPC. Within the AC-MPC entity, higher vimentin expression was correlated with more frequent vascular invasion and more advanced node metastasis (P<0.05), and multivariate analysis showed that high vimentin expression and worse node statuses were independent indicators of adverse prognosis (P<0.05). In conclusion, vimentin expression is prevalent and markedly up-regulated in MPC, which might reflect the biological essence of poorer differentiation or dedifferentiation of MPC, and this might have a role in the increase of invasiveness and consequent more malignant nature of MPC.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Prevalent and up-regulated vimentin expression in micropapillary components of lung adenocarcinomas and its adverse prognostic significance.2015
Author(s)
Nakashima H, Jiang SX, Sato Y, Hoshi K, Matsumoto T, Nagashio R, Kobayashi M, Matsuo Y, Shiomi K, Hayakawa K, Saegusa M, Satoh Y
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Journal Title
Pathol Int.
Volume: 65
Pages: 183-192
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] A CLINICOPATHOLOGICAL ANALYSIS OF PULMONARY ADENOCARCINOMA WITH MICROPAPILLARY COMPONENT
Author(s)
Hiroyasu Nakashima,Shi-Xu Jiang,Ryo Nagashio,Toshihide Matsumoto,Dai Ishii,Hirotsugu Yamazaki,Masahito Naitoh,Fumihior Ogawa,Yoshio Matsui,Yuichi Saitoh,Kazu Shiomi,Naomi Kurouzu,Hidenori Hara,Akira Iyoda,Yuichi Sato,Makoto Saegusa,Yukitoshi Satoh
Organizer
THE 21ST ANNUAL MEETING OF THE ASIAN SOCIETY FOR CARDIOVASCULAR AND THORACIC SURGERY
Place of Presentation
神戸
Related Report
