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Proteomic analysis of lung adenocarcinoma with micropapillary component to achieve valuable biomarker

Research Project

Project/Area Number 24592099
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionKitasato University

Principal Investigator

SATOH Yukitoshi  北里大学, 医学部, 教授 (90321637)

Co-Investigator(Kenkyū-buntansha) SATO Yuichi  北里大学, 医療衛生学部, 教授 (30178793)
JIANG Shi-Xu  北里大学, 医学部, 准教授 (70276153)
Research Collaborator NAKASHIMA Hiroyasu  北里大学, 医学部, 助教
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肺腺癌 / 微乳頭構造 / ビメンチン / 免疫組織化学染色 / 二次元電気泳動 / 網羅的タンパク発現解析 / Lung adenocarcinoma / Micropapillary pattern / Immunohistochemistry / Vimentin / micropapillary pattern / タンパク / 免疫染色 / 臨床病理学的因子 / micropapillary pattern / 網羅的解析 / 2次元電気泳動
Outline of Final Research Achievements

The factors conferrng the increased malignancy on lung adenocarcinoma with micropapillary component (AC-MPC) remain to be elucidated. 2-dimensional gel electrophoresis, several proteins differentially expressed between AC-MPC and conventional adenocarcinoma (CAC); in particular, vimentin, one of the proteins, was most up-regulated in AC-MPC. Immunohistochemistry revealed that vimentin was expressed in most of MPC. Within the AC-MPC entity, higher vimentin expression was correlated with more frequent vascular invasion and more advanced node metastasis (P<0.05), and multivariate analysis showed that high vimentin expression and worse node statuses were independent indicators of adverse prognosis (P<0.05). In conclusion, vimentin expression is prevalent and markedly up-regulated in MPC, which might reflect the biological essence of poorer differentiation or dedifferentiation of MPC, and this might have a role in the increase of invasiveness and consequent more malignant nature of MPC.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Prevalent and up-regulated vimentin expression in micropapillary components of lung adenocarcinomas and its adverse prognostic significance2015

    • Author(s)
      Nakashima H, Jiang SX, Sato Y, Hoshi K, Matsumoto T, Nagashio R, Kobayashi M, Matsuo Y, Shiomi K, Hayakawa K, Saegusa M, Satoh Y
    • Journal Title

      Pathol Int

      Volume: 65 Issue: 4 Pages: 183-192

    • DOI

      10.1111/pin.12257

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Higher incidence of postoperative up-staging in lung micropapillary adenocarcinoma.2015

    • Author(s)
      Hiroyasu Nakashima, Shi-Xu Jiang, Keika Hoshi, Makoto Saegusa, Yukitoshi Satoh.
    • Journal Title

      The Kitasato Medical Journal

      Volume: 45 Pages: 80-85

    • NAID

      40020413664

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] A clinicopathological and proteomic analysis of pulmonary adenocarcinoma with micropapillary component2014

    • Author(s)
      Hiroyasu Nakashima, Shi-Xu Jiang, Atsuko Umezawa, Kazu Shiomi, Yuichi Sato, Makoto Saegusa, Yukitoshi Satoh
    • Organizer
      第73回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] A CLINICOPATHOLOGICAL ANALYSIS OF PULMONARY ADENOCARCINOMA WITH MICROPAPILLARY COMPONENT2013

    • Author(s)
      中島 裕康、佐藤 之俊
    • Organizer
      Asian Society for Cardiovascular and Thoracic Surgery
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] A CLINICOPATHOLOGICAL ANALYSIS OF PULMONARY ADENOCARCINOMA WITH MICROPAPILLARY COMPONENT

    • Author(s)
      Hiroyasu Nakashima,Shi-Xu Jiang,Ryo Nagashio,Toshihide Matsumoto,Dai Ishii,Hirotsugu Yamazaki,Masahito Naitoh,Fumihior Ogawa,Yoshio Matsui,Yuichi Saitoh,Kazu Shiomi,Naomi Kurouzu,Hidenori Hara,Akira Iyoda,Yuichi Sato,Makoto Saegusa,Yukitoshi Satoh
    • Organizer
      THE 21ST ANNUAL MEETING OF THE ASIAN SOCIETY FOR CARDIOVASCULAR AND THORACIC SURGERY
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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