| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Mitochondria play a pivotal role not only in energy production but also in cell death. In addition, recent studies have revealed that mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Much attention has been paid to this phenomenon, called mitochondria biogenesis, in connection with various diseases. In this study, we elucidated the roles of mitochondria injury and biogenesis in ischemic neuronal injury and ischemic tolerance. Our results suggest that the expression change of mitochondria biogenesis related protein would lead apoptosis after ischemia, and mitochondria fusion might be associated with acquisition of ischemic tolerance.
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