| Project/Area Number |
24592133
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAWATA Toshio 高知大学, 教育研究部医療学系, 助教 (40380323)
UEBA Tetsuya 高知大学, 教育研究部医療学系, 教授 (00314203)
FUJIMOTO Yasunori 高知大学, 教育研究部医療学系, 講師 (80589789)
SHIMIZU Keiji 高知大学, 教育研究部医療学系, 教授 (70116044)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 頭部外傷 / うつ病 / 脳内亜鉛 / グリア細胞 / 脳保護薬 / 活性酸素 / 5-lipoxygenase / アストロサイト |
|---|
| Outline of Final Research Achievements |
We examined whether complex polysaccharide and lipopolysaccharide effect on concussion-induced depressive-like behavior in mice, but they had no effect on depressive-like behavior in the forced swim test.
Furthermore, we investigated the effect of a membrane-permeable zinc chelater (ZC) or a free radical scavenger edaravone (Ed) on concussion-induced depressive-like behavior. Mice were intravenously administered ZC and Ed before and immediately after impact, respectively. We found that ZC suppressed depressive-like behavior and microglial activation in the hippocampus 1 day after concussion. Ed also attenuated concussion-induced depressive-like behavior, which was accompanied by inhibition of increased hippocampal oxidative stress and suppression of 5-lipoxygenase activation in hippocampal astrocytes. These results suggest that ZC and Ed protect against concussion-induced depression, and these protections are mediated by suppression of glial cell-associated brain inflammation.
|
