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Development and clinical application of new noninvasive diagnostic imaging of the misery perfusion due to the cerebrovascular obstructive lesion

Research Project

Project/Area Number 24592142
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionIwate Medical University

Principal Investigator

KOBAYASHI Masakazu  岩手医科大学, 医学部, 助教 (60364345)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords脳循環代謝 / MRI / PET / SPECT / 慢性脳主幹動脈病変 / MRS / 脳主幹動脈病変
Outline of Final Research Achievements

Positoron Emission Tomography(PET), an examination of brain blood flow Single Photon Emission Computed Tomography(SPECT) are conducted for the recurrence risk prediction of the chronic brain chief editor arterial obstruction stenosis-related disease widely, but these need special facilities, drug, and problems include side effects for the drug (contrast media, acetazolamide) use. Therefore it was the place where development of the noninvasive new brain circulation metabolism measurement was expected. Brain circulation metabolism measured the PET that was gold standard of the brain circulation measurement this time, brain blood flow SPECT by measured of brain temperature using 3T-MRS, a susceptibility image using 3T-MRI, the iomazenil SPECT measurement for an index and studied possibility of the precision confirmation and the fruit clinical use.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Noninvasive evaluation of collateral blood flow through circle of Willis in cervical carotid stenosis using selective cerebral magnetic resonance angiography2014

    • Author(s)
      Ito K, Sasaki M, Kobayashi M, Ogasawara K, Nishihara T, Takahashi T, Natori T, Uwano I, Yamashita F, Kudo K.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 23(5) Pages: 1019-1023

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting carotid plaque characteristics using quantitative color-coded T1-weighted MR plaque imaging: correlation with carotid endarterectomy specimens.2014

    • Author(s)
      Narumi S, Sasaki M, Ohba H, Ogasawara K, Kobayashi M, Natori T, Hitomi J, Itagaki H, Takahashi T, Terayama Y.
    • Journal Title

      AJNR Am J Neuroradiol.

      Volume: 35(4) Issue: 4 Pages: 766-771

    • DOI

      10.3174/ajnr.a3741

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Noninvasive evaluation of collateral blood flow through circle of willis in cervical carotid stenosis using selective Magnetic Resonance Angiography2013

    • Author(s)
      Ito K, Sasaki M, Kobayashi M, Ogasawara K, Nishihara T, Takahashi T, Natori T, Uwano I, Yamashita F, Kudo K
    • Journal Title

      J Stroke Cerebrovasc Dis. 2013 Oct 5. pii: S1052-3057(13)00347-9.

      Volume: 13 Issue: 5 Pages: 347-9

    • DOI

      10.1016/j.jstrokecerebrovasdis.2013.08.018

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in cognitive function after carotid endarterectomy in older patients: comparison with younger patients.2013

    • Author(s)
      Takahashi Y, Ogasawara K, Matsumoto Y, Kobayashi M, Yoshida K, Kubo Y, Beppu T, Murakami T, Nanba T, Ogawa A.
    • Journal Title

      Neurol Med Chir (Tokyo). 2013;53(6):353-9.

      Volume: 53 Pages: 353-9

    • NAID

      10031173717

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Postoperative increase in cerebral white matter fractional anisotropy on diffusion tensor magnetic resonance imaging is associated with cognitive improvement after uncomplicated carotid endarterectomy: tract-based spatial statistics analysis.2013

    • Author(s)
      Sato Y, Ito K, Ogasawara K, Sasaki M, Kudo K, Murakami T, Nanba T, Nishimoto H, Yoshida K, Kobayashi M, Kubo Y, Mase T, Ogawa A
    • Journal Title

      Neurosurgery.

      Volume: 73(4) Issue: 4 Pages: 592-8

    • DOI

      10.1227/neu.0000000000000013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of misery perfusion in the cerebral hemisphere with chronic unilateral major cerebral artery steno-occlusive disease using crossed cerebellar hypoperfusion: comparison of brain SPECT and PET imaging.2013

    • Author(s)
      Matsumoto Y, Ogasawara K, Saito H, Terasaki K, Takahashi Y, Ogasawara Y, Kobayashi M, Yoshida K, Beppu T, Kubo Y, Fujiwara S, Tsushima E, Ogawa A
    • Journal Title

      Eur J Nucl Med Mol Imaging.

      Volume: 40(10) Issue: 10 Pages: 1573-81

    • DOI

      10.1007/s00259-013-2463-2

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ischemic events due to intraoperative microemboli developing in the cerebral hemisphere contralateral to carotid endarterectomy in a patient with preoperative cerebral hemodynamic impairment.2012

    • Author(s)
      Kobayashi M, Ogasawara K, Suzuki T, Kuroda H, Yamashita T, Yoshida K, Kubo Y, Ogawa A.
    • Journal Title

      Neurol Med Chir (Tokyo).

      Volume: 52(3) Pages: 161-164

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 頚動脈内膜剥離術後過灌流の予知にアセタゾラミド負荷は必要か?~安静時脳血流量測定単独との精度比較2015

    • Author(s)
      小林正和、小笠原邦昭、大志田創太郎、佐浦宏明、吉田浩二、藤原俊朗、小島大悟、吉田研二、久保慶高、小川彰
    • Organizer
      日本脳神経CI学会
    • Place of Presentation
      愛知産業労働センター
    • Year and Date
      2015-02-13 – 2015-02-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 頚動脈内膜剥離術における頚動脈露出操作中の意図的昇圧は微小塞栓による脳虚巣出現を予防する2012

    • Author(s)
      小林正和、小笠原邦昭、吉田研二、黒田博紀、鈴木太郎、久保慶高、藤原俊朗、小川彰
    • Organizer
      第31回日本脳神経超音波学会総会
    • Place of Presentation
      埼玉県大宮ソニックシティ
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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