Establishment of the new cerebral circulation metabolic index based on redox analysis at the transient cerebral ischemia and reperfusion
Project/Area Number |
24592144
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cerebral neurosurgery
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Research Institution | Iwate Medical University |
Principal Investigator |
YOSHIDA kenji 岩手医科大学, 医学部, 講師 (10316367)
|
Co-Investigator(Renkei-kenkyūsha) |
OGASAWARA Kuniaki 岩手医科大学, 医学部, 教授 (00305989)
KOBAYASHI Masakazu 岩手医科大学, 医学部, 助教 (60364345)
FUJIEARA Shunrou 岩手医科大学, 医学部, 助教 (60405842)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 脳血管障害 / 慢性脳虚血 / 虚血再潅流 / フリーラジカル / 虚血 / 再潅流 / 過灌流 / 脳虚血 / プロテオーム / 脳循環代謝 |
Outline of Final Research Achievements |
We examined the connection with free radicals such as the peroxynitrite in during the ischemia and the reperfusion, NO, specific protein in this study and groped for the index that could evaluate cerebral ischaemia. Also, for chronic cerebral ischaemia-related disease, we examined establishment by the cerebral circulation residual function evaluation that was intactness by 7 tesla MRI. From the development of cerebral infarction, we were able to confirm NO elevation of the jugular vein blood. We were able to confirm NO elevation of the jugular vein blood. An OEF image in the PET and a very good correlation were suggested by 7 tesla MRI.
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Report
(4 results)
Research Products
(79 results)
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[Journal Article] Does Preoperative Measurement of Cerebral Blood Flow with Acetazolamide Challenge in Addition to Preoperative Measurement of Cerebral Blood Flow at the Resting State Increase the Predictive Accuracy of Development of Cerebral Hyperperfusion after Carotid Endarterectomy? Results from 500 Cases with Brain Perfusion Single-photon Emission Computed Tomography Study2015
Author(s)
Oshida S, Ogasawara K, Saura H, Yoshida K, Fujiwara S, Kojima D, Kobayashi M, Yoshida K, Kubo Y, Ogawa A
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Journal Title
Neurologia medico-chirurgica
Volume: 55
Issue: 2
Pages: 141-148
DOI
NAID
ISSN
0470-8105, 1349-8029
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Detection of misery perfusion in the cerebral hemisphere with chronic unilateral major cerebral artery steno-occlusive disease using crossed cerebellar hypoperfusion: comparison of brain SPECT and PET imaging.2013
Author(s)
Matsumoto Y, Ogasawara K, Saito H, Terasaki K, Takahashi Y, Ogasawara Y, Kobayashi M, Yoshida K, Beppu T, Kubo Y, Fujiwara S, Tsushima E, Ogawa A
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Journal Title
Eur J Nucl Med Mol Imaging.
Volume: 40(10)
Issue: 10
Pages: 1573-81
DOI
Related Report
Peer Reviewed
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[Journal Article] Postoperative changes in cerebral metabolites associated with cognitive improvement and impairment after cartid endarterectomy: A 3T proton MR spectroscopy study2013
Author(s)
Saito H., Ogasawara K., Nishimoto H., Yoshioka Y., Murakami H., Fujiwara S., Sasaki M., Kobayashi M., Yoshida K., Kubo Y., Beppu T., Ogawa A.
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Journal Title
American Journal of Neuroradiology
Volume: 34
Issue: 5
Pages: 976-982
DOI
Related Report
Peer Reviewed
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[Journal Article] Postoperative cerebral white matter damage associated with cerebral hyperperfusion and cognitive impairment after carotid endarterectomy: a diffusion tensor magnetic resonance imaging study2012
Author(s)
Nanba T., Ogasawara K., Nishimoto H., Fujiwara S., Kuroda H., Sasaki M., Kudo K., Suzuki T., Kobayashi M., Yoshida K., Ogawa A.
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Journal Title
Cerebrovascular Diseases
Volume: 34
Pages: 358-367
Related Report
Peer Reviewed
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