| Project/Area Number |
24592144
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
YOSHIDA kenji 岩手医科大学, 医学部, 講師 (10316367)
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| Co-Investigator(Renkei-kenkyūsha) |
OGASAWARA Kuniaki 岩手医科大学, 医学部, 教授 (00305989)
KOBAYASHI Masakazu 岩手医科大学, 医学部, 助教 (60364345)
FUJIEARA Shunrou 岩手医科大学, 医学部, 助教 (60405842)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳血管障害 / 慢性脳虚血 / 虚血再潅流 / フリーラジカル / 虚血 / 再潅流 / 過灌流 / 脳虚血 / プロテオーム / 脳循環代謝 |
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| Outline of Final Research Achievements |
We examined the connection with free radicals such as the peroxynitrite in during the ischemia and the reperfusion, NO, specific protein in this study and groped for the index that could evaluate cerebral ischaemia. Also, for chronic cerebral ischaemia-related disease, we examined establishment by the cerebral circulation residual function evaluation that was intactness by 7 tesla MRI.
From the development of cerebral infarction, we were able to confirm NO elevation of the jugular vein blood. We were able to confirm NO elevation of the jugular vein blood. An OEF image in the PET and a very good correlation were suggested by 7 tesla MRI.
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