Analysis of dynamics in epileptic network with new method of MEG and functional MRI

• Project/Area Number: 24592159
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kyoto University
• Principal Investigator: KUNIEDA Takeharu 京都大学, 医学(系)研究科(研究院), 講師 (60609931)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Riki 京都大学, 医学研究科, 准教授 (00378754) ; MATSUHASHI Masao 京都大学, 学内共同利用施設等, 准教授 (40456885) ; MIYAMOTO Susumu 京都大学, 医学研究科, 教授 (70239440) ; SAWAMOTO Nobukatsu 京都大学, 医学研究科, 講師 (90397547)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 難治性てんかん / ネットワーク / MEG / 空間フィルター法 / 機能的MRI / てんかん / 脳磁図 / fMRI

Outline of Final Research Achievements

In recent years, although it is suggested that clinical condition of epilepsy forms pathologically complicated neural network, the extent of the epileptic areas and its organization in detail have not been clarified yet. We successfully visualized the spatial and temporal organization of epileptogenecity by means of the spatial filter analysis of magnetoencephalogram (MEG), instead of the conventional analysis of equivalent electric current dipole (ECD) model. Through comparison with non-invasive functional imaging and invasive analyzing technique of neural network, we inspected the validity and clinical significance of the spatial filter analysis, and added new knowledge in understanding pathological condition of intractable epilepsy.

Research Products

• [Journal Article] Risk factors for infective complications with long term subdural electrode implantation in patients with medically intractable partial epilepsy. (2015)
  • Author(s): Shibata, S., T. Kunieda, R. Inano, M. Sawada, Y. Yamao, T. Kikuchi, R. Matsumoto, A. Ikeda, R. Takahashi, N. Mikuni, J. Takahashi and S. Miyamoto
  • Journal Title: World Neurosurg Volume: - Issue: 2 Pages: 320-326
  • DOI: 10.1016/j.wneu.2015.03.048
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Voxel-based clustered imaging by multiparameter diffusion tensor images for glioma grading (2014)
  • Author(s): Inano Rika, Oishi Naoya, Kunieda Takeharu, Arakawa Yoshiki, Yamao Yukihiro, Shibata Sumiya, Kikuchi Takayuki, Fukuyama Hidenao, Miyamoto Susumu
  • Journal Title: NeuroImage: Clinical Volume: 5 Pages: 396-407
  • DOI: 10.1016/j.nicl.2014.08.001
  • NAID: 120005477685
  • Peer Reviewed / Open Access
• [Journal Article] Neural correlates of mirth and laughter: A direct electrical cortical stimulation study. (2014)
  • Author(s): Yamao, Y., R. Matsumoto, T. Kunieda, S. Shibata, A. Shimotake, T. Kikuchi, T. Satow, N. Mikuni, H. Fukuyama, A. Ikeda and S. Miyamoto
  • Journal Title: Cortex Volume: - Pages: 134-40
  • DOI: 10.1016/j.cortex.2014.11.008
  • NAID: 120005749923
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation. (2014)
  • Author(s): Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S.
  • Journal Title: Hum Brain Mapp Volume: 印刷中 Issue: 9 Pages: 74-85
  • DOI: 10.1002/hbm.22479
  • Peer Reviewed / Open Access
• [Journal Article] Long-term seizure outcome following resective surgery for epilepsy: to be or not to be completely cured? (2013)
  • Author(s): Kunieda, T., N. Mikuni, S. Shibata, R. Inano, Y. Yamao, T. Kikuchi, R. Matsumoto, J. Takahashi, A. Ikeda, H. Fukuyama and S. Miyamoto
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 53 Pages: 805-813
  • Peer Reviewed
• [Journal Article] Pre-SMA actively engages in conflict processing in human: a combined study of epicortical ERPs and direct cortical stimulation. (2013)
  • Author(s): Usami, K., Matsumoto, R., Kunieda, T., Shimotake, A., Matsuhashi, M., Miyamoto, S., Fukuyama, H., Takahashi, R., & Ikeda, A.
  • Journal Title: Neuropsychologia Volume: 51 Issue: 5 Pages: 1011-1017
  • DOI: 10.1016/j.neuropsychologia.2013.02.002
  • NAID: 120005244967
  • Peer Reviewed
• [Journal Article] Epilepsy surgery: surgical aspects (2012)
  • Author(s): Kunieda, T. Kikuchi, T. Miyamoto, S.
  • Journal Title: Curr Opin Anaesthesiol Volume: 25 Issue: 5 Pages: 533-9
  • DOI: 10.1097/aco.0b013e32835774d4
  • NAID: 120005394883
  • Peer Reviewed
• [Journal Article] [In vivo investigation of human brain networks by using cortico-cortical evoked potentials] (2012)
  • Author(s): Matsumoto, R. Kunieda, T. Ikeda, A.
  • Journal Title: Brain Nerve Volume: 64 Pages: 979-91
  • NAID: 40019424207
  • Peer Reviewed
• [Journal Article] Anterior temporal lobe white matter abnormal signal (ATLAS) as an indicator of seizure focus laterality in temporal lobe epilepsy: comparison of double inversion-recovery, FLAIR and T2W MR imaging (2012)
  • Author(s): Morimoto E, Kanagaki M, Okada T, Yamamoto A, Mori N, Matsumoto R, Ikeda A, Mikuni N, Kunieda T, Paul D, Miyamoto S, Takahashi R, Togashi K
  • Journal Title: Eur Radiol Volume: 23 Issue: 1 Pages: 3-11
  • DOI: 10.1007/s00330-012-2565-4
  • Peer Reviewed
• [Presentation] Wada testにおける記憶の評価 (2015)
  • Author(s): 稲野理賀
  • Organizer: 日本定位・機能神経外科学会
  • Place of Presentation: 東京
  • Year and Date: 2015-01-16 – 2015-01-17
• [Presentation] Preoperative evaluation of language and memory dominance estimated by intracarotid propofol test (2014)
  • Author(s): Takeharu Kunieda
  • Organizer: 68th annual meeting of American Epilepsy Society
  • Place of Presentation: Seattle
  • Year and Date: 2014-12-05 – 2014-12-09
• [Presentation] Intraoperative Supplementary Motor Area (SMA) Monitoring for Medial Frontal Lesions (2014)
  • Author(s): Sumiya Shibata
  • Organizer: 68th annual meeting of American Epilepsy Society
  • Place of Presentation: Seattle
  • Year and Date: 2014-12-05 – 2014-12-09
• [Presentation] 皮質単発刺激による誘発律動反応の生理学的検討 (2014)
  • Author(s): 中江卓郎
  • Organizer: 日本臨床神経生理学会
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-19 – 2014-11-21
• [Presentation] 皮質―皮質間誘発電位を用いた言語機能の術中モニタリングへの応用 (2014)
  • Author(s): 國枝武治
  • Organizer: 日本脳神経外科学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-09 – 2014-10-11
• [Presentation] MEGをもちいた薬剤難治性てんかん患者における安静時脳内ネットワークの研究：少数陽性例の検討 (2014)
  • Author(s): 芝田純也
  • Organizer: 日本脳神経外科学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-09 – 2014-10-11
• [Presentation] DTIによるマルチパラメータを用いた非侵襲的なグリオーマの悪性度予測 (2014)
  • Author(s): 稲野理賀
  • Organizer: 日本脳神経外科学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-09 – 2014-10-11
• [Presentation] 優位側側頭葉の病変切除手術における意味性言語機能の変化と切除範囲の検討 (2014)
  • Author(s): 中江卓郎
  • Organizer: 日本脳神経外科学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-09 – 2014-10-11
• [Presentation] MRIによるSMAの分離の試み-電気生理学的所見との比較- (2014)
  • Author(s): 西田誠
  • Organizer: 日本脳神経外科学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-09 – 2014-10-11
• [Presentation] てんかん手術における頭蓋内深部電極・硬膜下電極の併用留置 (2014)
  • Author(s): 國枝武治
  • Organizer: 日本てんかん学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-02 – 2014-10-03
• [Presentation] 経時的なMRI検査によりてんかん焦点を確認しえた一症例 (2014)
  • Author(s): 西田誠
  • Organizer: てんかん学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-02
• [Presentation] Dual pathologyが疑われて頭蓋内電極留置により診断した難治性側頭葉てんかんの一例 (2014)
  • Author(s): 稲田拓
  • Organizer: 日本脳神経外科学会近畿支部学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-05
• [Presentation] てんかん手術における頭蓋内深部電極の有用性 (2013)
  • Author(s): 國枝武治
  • Organizer: 第72回脳神経外科学会総会
  • Place of Presentation: 横浜
• [Presentation] ANALYSIS OF SOMATOSENSORY EVOKED FIELD BY USING TEMPORAL SPREAD IMAGE (2013)
  • Author(s): Sumiya Shibata
  • Organizer: ISACM 2013
  • Place of Presentation: 札幌
• [Presentation] てんかん外科術前検査におけるMEGの有用性 ―病変診断と機能検査― (2013)
  • Author(s): 芝田純也
  • Organizer: 第28回日本生体磁気学会
  • Place of Presentation: 新潟
• [Presentation] Long-term Seizure Outcome following Resective Surgery for Epilepsy (2013)
  • Author(s): Takeharu Kunieda
  • Organizer: American Epilepsy Society Annual meeting
  • Place of Presentation: Washington DC
• [Presentation] Magnetoencephalography with Temporal Spread Image Method Could Show Propagation of Epileptic Activities (2013)
  • Author(s): Sumiya Shibata
  • Organizer: American Epilepsy Society Annual meeting
  • Place of Presentation: Washington DC
• [Presentation] Negative motor seizureで発症し、覚醒下手術中にsupplementary negative motor areaをmappingできた一例. (2013)
  • Author(s): 山尾幸広、國枝武治、荒川芳輝、松本理器、芝田純也、稲野理賀、菊池隆幸、池田昭夫、宮本享
  • Organizer: 第36回てんかん外科学会
  • Place of Presentation: 岡山
• [Presentation] Motor function after surgery: correlation between outcome and motor network connectivity. (2012)
  • Author(s): Yamao Y, Sawamoto N, Kunieda T, Shibata S, Kikuchi T, Matsumoto R, Ikeda A, Fukuyama H, Miyamoto S
  • Organizer: The 18th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Beijing, China
• [Presentation] Intraoperative monitoring of perisylvian language network by means of cortico-cortical evoked potentials. (2012)
  • Author(s): Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Takahashi R, Ikeda A, Fukuyama H, Miyamoto S
  • Organizer: Neuroscience 2012,Society for Neuroscience (SfN) 42nd Annual meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] 皮質-皮質間誘発電位を用いた言語白質線維路の術中モニタリング法の開発. (2012)
  • Author(s): 山尾幸広、松本理器、國枝武治、荒川芳輝、菊池隆幸、芝田純也、稲野理賀、澤本伸克、三國信啓、池田昭夫、福山秀直、宮本享
  • Organizer: 日本脳神経外科学会 第71回学術総会
  • Place of Presentation: 大阪
• [Presentation] 覚醒下手術においてプロポフォールが皮質脳波に与える影響 (2012)
  • Author(s): 芝田純也、國枝武治、稲野理賀、澤田真寛、山尾幸広、菊池隆幸、小林勝哉、宇佐美清英、金澤恭子、下竹昭寛、今村久司、松本理器、池田昭夫、宮本享
  • Organizer: 日本脳神経外科学会 第71回学術総会
  • Place of Presentation: 大阪
• [Presentation] 内側側頭葉てんかんにおけるてんかん性脳波活動の進展様式 (2012)
  • Author(s): 芝田純也、松橋眞生、國枝武治、山尾幸広、稲野理賀、菊池隆幸、今村久司、高屋成利、松本理器、池田昭夫、高橋良輔、福山秀直、三國信啓、宮本享
  • Organizer: 日本てんかん学会
  • Place of Presentation: 東京
• [Presentation] MRI上明らかな病変を認めず、脳磁図（MEG）検査が焦点探索に有効であった難治てんかんの一例 (2012)
  • Author(s): 芝田純也、松橋眞生、國枝武治、荒川芳輝、菊池隆幸、横山洋平、山尾幸広、三國信啓、松本理器、今村久司、麓直浩、下竹昭寛、高屋成利、宮本享、池田昭夫
  • Organizer: 日本てんかん学会
  • Place of Presentation: 東京
• [Presentation] Intraoperative monitoring of perisylvian language network bymeans of cortico-cortical evoked potentials. (2012)
  • Author(s): Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Shibata S, Kikuchi T, Sawamoto S, Takahashi R, Ikeda A, Fukuyama H, Miyamoto S
  • Organizer: 第35回日本神経科学大会(Neuro2012)
  • Place of Presentation: 名古屋
• [Book] 症例から学ぶ戦略的てんかん診断・治療 (2014)
  • Author(s): 國枝武治、（編集）池田昭夫・松本理器・木下真幸子
  • Total Pages: 242
  • Publisher: 南山堂
• [Book] てんかん患者の脳画像診断 (2012)
  • Author(s): 山尾幸広、松橋眞生、國枝武治、福山秀直
  • Publisher: 株式会社メジカルビュー社