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Influence of Glioblastoma stem cells to the escape phenomenon in immunotherapy including WT1 vaccination

Research Project

Project/Area Number 24592160
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionOsaka University

Principal Investigator

KAGAWA Naoki  大阪大学, 医学(系)研究科(研究院), 助教 (50444542)

Co-Investigator(Kenkyū-buntansha) HOSEN Naoki  大阪大学, 大学院医学系研究科・寄附講座, 准教授 (10456923)
HASHIMOTO Naoya  京都府立医科大学, 大学院医学系研究科, 准教授 (90315945)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsWT1 / ALCAM / 主要幹細胞 / 腫瘍内免疫 / 腫瘍幹細胞 / 脳腫瘍幹細胞 / 神経膠腫
Outline of Final Research Achievements

We found activated leukocyte cell adhesion molecule (ALCAM) was highly expressed on glioblastoma progenitor cells and ALCAM and its soluble isoform were involved in glioblastoma invasion, progression and angiogenesis. About IDH1-R132H-positve gliomas, the frequency of ALCAM-positive cells was significantly higher in WHO grade IV than in II or III. In primary glioblastomas, median PFS and OS for the patients with high percentage of positive cells was significantly worse. Group showing periventricular origin at initial diagnosis and/or diffuse invasive recurrence more highly expressed ALCAM, compared with others.
We have also shown that the escape phenomena from WT1 vaccination was in part due to a decrease of WT1/HLA class I molecule expression and increase of Treg in tumor microenvironment. ALCAM may influence the escape phenomenon inducing Treg invasion in GBM.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (81 results)

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article (22 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 19 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (59 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide2016

    • Author(s)
      Oji Y, Hashimoto N, Tsuboi A, Murakami Y, Iwai M, Kagawa N, Chiba Y, Izumoto S, Eliseeva O, Ichinohasama R, Sakamoto J, Morita S, Nakajima H, Takashima S, Nakae Y, Nakata J, Kawakami M, Nishida S, Hosen N, Fujiki F, Morimoto S, Adachi M, Iwamoto M, Oka Y, Yoshimine T, Sugiyama H
    • Journal Title

      Int J Cancer

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.2016

    • Author(s)
      Thompson EM, Hielscher T, Bouffet E, Remke M, Luu B, Kagawa N, Hashimoto N, Jabado N, Shih DJ, Kijima N, Northcott PA, Kool M, Jones DT, Chan JA, Hawkins CE, Tabori U, Drake J, Kulkarni A, Dirks P, Rutka JT, Korshunov A, Pfister SM, Packer RJ, Ramaswamy V, Taylor MD.
    • Journal Title

      Lancet Oncol.

      Volume: 17(4) Issue: 4 Pages: 484-495

    • DOI

      10.1016/s1470-2045(15)00581-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of diffusion tensor imaging and 11C-methionine positron emission tomography for reliable prediction of tumor cell density in gliomas.2016

    • Author(s)
      Kinoshita M, Arita H, Okita Y, Kagawa N, Kishima H, Hashimoto N, Tanaka H, Watanabe Y, Shimosegawa E, Hatazawa J, Fujimoto Y, Yoshimine T.
    • Journal Title

      J Neurosurg.

      Volume: - Pages: 1-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic and Prognostic Value of 11C-Methionine PET for Nonenhancing Gliomas.2016

    • Author(s)
      Takano K, Kinoshita M, Arita H, Okita Y, Chiba Y, Kagawa N, Fujimoto Y, Kishima H, Kanemura Y, Nonaka M, Nakajima S, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T.
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 37 Issue: 1 Pages: 44-50

    • DOI

      10.3174/ajnr.a4460

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response2015

    • Author(s)
      Naoya Hashimoto, Akihiro Tsuboi, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Norio Arita, Toshiki Yoshimine, Haruo Sugiyama
    • Journal Title

      Cancer Immunology Immunotherapy

      Volume: - Issue: 6 Pages: 707-16

    • DOI

      10.1007/s00262-015-1674-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Peptide vaccination therapy against brain tumors2015

    • Author(s)
      Hashimoto N, Kagawa N, Arita H, Tsuboi A, Oka Y, Oji Y, Sugiyama H, Yoshimine T.
    • Journal Title

      Gan To Kagaku Ryoho.

      Volume: 42(6) Pages: 687-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 3.Treatment outcomes using CyberKnife for brain metastases from lung cancer.2014

    • Author(s)
      Tamari K, Suzuki O, Hashimoto N, Kagawa N, Fujiwara M, Sumida I, Seo Y , Isohashi F, Yoshioka Y, Yoshimine T, Ogawa K.
    • Journal Title

      J Radiat Res

      Volume: - Issue: 1 Pages: 151-8

    • DOI

      10.1093/jrr/rru092

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 1.Wilms' tumor 1 is involved in tumorigenicity of glioblastoma by regulating cell proliferation and apoptosis.2014

    • Author(s)
      Kijima N, Hosen N, Kagawa N, Hashimoto N, Kinoshita M, Oji Y, Sugiyama H, Yoshimine T
    • Journal Title

      Anticancer Res.

      Volume: 34 Pages: 61-67

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 2.Different spatial distribution between germinal center B and non-germinal center B primary central nervous system lymphoma revealed by magnetic resonance group analysis.2014

    • Author(s)
      Kinoshita M1, Sasayama T, Narita Y, Yamashita F, Kawaguchi A, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohno M, Miyakita Y, Shibui S, Hashimoto N, Yoshimine T
    • Journal Title

      Neuro Oncol

      Volume: 16 Issue: 5 Pages: 728-734

    • DOI

      10.1093/neuonc/not319

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Different spatial distribution between germinal center B and non-germinal center B primary central nervous system lymphoma revealed by magnetic resonance group analysis.2014

    • Author(s)
      Kinoshita M, Sasayama T, Narita Y, Yamashita F, Kawaguchi A, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohno M, Miyakita Y, Shibui S, Hashimoto N, Yoshimine T.
    • Journal Title

      Neuro Oncol.

      Volume: 印刷中

    • Related Report
      2013 Research-status Report
  • [Journal Article] lms' tumor 1 is involved in tumorigenicity of glioblastoma by regulating cell proliferation and apoptosis.2014

    • Author(s)
      Kijima N, Hosen N, Kagawa N, Hashimoto N, Kinoshita M, Oji Y, Sugiyama H, Yoshimine T.
    • Journal Title

      Anticancer Res.

      Volume: 34(1) Pages: 61-7

    • Related Report
      2013 Research-status Report
  • [Journal Article] Training to acquire psychomotor skills for endoscopic endonasal surgery using a personal webcam trainer.2013

    • Author(s)
      Hirayama R, Fujimoto Y, Umegaki M, Kagawa N, Kinoshita M, Hashimoto N, Yoshimine T.
    • Journal Title

      10.3171/2012.12.JNS12908

      Volume: 118(5) Pages: 1120-6

    • Related Report
      2013 Research-status Report
  • [Journal Article] Radiation-induced anaplastic ependymoma with a remarkable clinical response to temozolomide: a case report.2013

    • Author(s)
      Khoo HM, Kishima H, Kinoshita M, Goto Y, Kagawa N, Hashimoto N, Maruno M, Yoshimine T.
    • Journal Title

      Br J Neurosurg

      Volume: 27(2) Issue: 2 Pages: 259-61

    • DOI

      10.3109/02688697.2012.741740

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Training to acquire psychomotor skills for endoscopic endonasal surgery using a personal webcam trainer.2013

    • Author(s)
      Hirayama R, Fujimoto Y, Umegaki M, Kagawa N, Kinoshita M, Hashimoto N, Yoshimine T.
    • Journal Title

      J Neurosurg.

      Volume: 118(5) Issue: 5 Pages: 1120-6

    • DOI

      10.3171/2012.12.jns12908

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Slower growth of skull base meningiomas compared with non-skull base meningiomas based on volumetric and biological studies.2012

    • Author(s)
      Hashimoto N, Rabo CS, Okita Y, Kinoshita M, Kagawa N, Fujimoto Y, Morii E, Kishima H, Maruno M, Kato A, Yoshimine T
    • Journal Title

      J Neurosurg

      Volume: 116 Pages: 574-580

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] (11) C-methiomne uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma : A stereotactic imaee-histological analysis2012

    • Author(s)
      Arita H
    • Journal Title

      Cancer

      Volume: 118(6) Issue: 6 Pages: 1619-1627

    • DOI

      10.1002/cncr.26445

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma.2012

    • Author(s)
      Chiba Y, Kinoshita M, Okita Y, Tsuboi A, Isohashi K, Kagawa N, Fujimoto Y, Oji Y, Oka Y, Shimosegawa E, Morita S, Hatazawa J, Sugiyama H, Hashimoto N, Yoshimine T
    • Journal Title

      J Neurosurg

      Volume: 116 Pages: 835-842

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Imaging (18)F-fluorodeoxy glucose/(11)C-methionine uptake decoupling for identification of tumor cell infiltration in peritumoral brain edema2012

    • Author(s)
      Kinoshita M
    • Journal Title

      J Neurooncol

      Volume: 106(2) Issue: 2 Pages: 417-425

    • DOI

      10.1007/s11060-011-0688-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of meningiomas assessed by (11)C-methionine and (18)F-fluorodeoxyglucose positron-emission tomography2012

    • Author(s)
      Arita H
    • Journal Title

      J Neurooncol

      Volume: 107(2) Issue: 2 Pages: 379-386

    • DOI

      10.1007/s11060-011-0759-2

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biased usage of T cell receptor β-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8^+ T cells in patients with solid tumors and healthy donors2012

    • Author(s)
      Morimoto S., et al
    • Journal Title

      Cancer Science

      Volume: 103 Issue: 3 Pages: 408-414

    • DOI

      10.1111/j.1349-7006.2011.02163.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] CD166/Activated leukocyte cell adhesion molecule is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion2011

    • Author(s)
      Noriyuki Kijima
    • Journal Title

      Neuro-Oncology

      Volume: (in press) Issue: 10 Pages: 1254-1264

    • DOI

      10.1093/neuonc/nor202

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hepatitis B virus reactivation associated with temozolomide for malignant glioma : a case report and recommendation for prophylaxis2011

    • Author(s)
      Yasunori Fujimoto
    • Journal Title

      International Journal of Clinical Oncology

      Volume: (in press) Issue: 3 Pages: 290-293

    • DOI

      10.1007/s10147-011-0294-3

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 小児再発性神経膠芽腫およびび漫性橋神経膠腫に対するWT1ペプチドワクチン療法の安全性と有効性2016

    • Author(s)
      香川尚己、橋井佳子、千葉泰良、平山龍一、有田英之、藤本康倫、橋本直哉、杉山治夫、吉峰俊樹
    • Organizer
      第43回日本小児神経外科学会
    • Place of Presentation
      筑波
    • Year and Date
      2016-06-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Hypersensitivity of intracranial germinomas for low-dose radiation: relationship between diagnostic radiation dose and volumetric changes before chemoradiotherapy2016

    • Author(s)
      Naoki Kagawa, Ryuichi Hirayama, Yasunori Fujimoto, Yasuyoshi Chiba, Chisato Yokota, Shogo Fukuya, Daisuke Eino, Koji Takano, Manabu Kinoshita, Naoya Hashimoto, Toshiki Yoshimine
    • Organizer
      17thInternational Symposium on Pediatric Neuro-Oncology
    • Place of Presentation
      Liverpool (United Kingdom)
    • Year and Date
      2016-06-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Immunotherapy of Wilms tumor 1 peptide vaccination against recurrent glioblastoma and diffuse intrinsic pontine glioma in children2016

    • Author(s)
      Naoki Kagawa, Yoshiko Hashii, Ryuichi Hirayama, Yasuyoshi Chiba, Takako Miyamura, Hideyuki Arita, Yasunori Fujimoto, Naoya Hashimoto, Haruo Sugiyama, Toshiki Yoshimine
    • Organizer
      17thInternational Symposium on Pediatric Neuro-Oncology
    • Place of Presentation
      Liverpool (United Kingdom)
    • Year and Date
      2016-06-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経膠芽腫における微小血管増生と分子マーカーとの関係についての考察2016

    • Author(s)
      香川尚己、永野大輔、有田英之、福屋章悟、平山龍一、高野浩司、福永貴典、藤本康倫、森井英一、吉峰俊樹
    • Organizer
      第34回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Year and Date
      2016-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 頭蓋内胚細胞腫の放射線感受性に関する後方視的検討-体積変化と被曝線量との関係-2015

    • Author(s)
      香川尚己、平山龍一、千葉泰良、藤本康倫、福屋章悟、永野大輔、高野浩司、福永貴典、横田千里、有田英之、木下学、橋本直哉、丸野元彦、吉峰俊樹
    • Organizer
      第33回日本脳腫瘍学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウスグリオーマ脳腫瘍モデルを用いたWT1ペプチドワクチン療法の検討2015

    • Author(s)
      福永貴典、高野浩司、千葉泰良、中島博子、福屋章悟、永野大輔、平山龍一、有田英之、香川尚己、藤本康倫、橋本直哉、吉峰俊樹
    • Organizer
      第33回日本脳腫瘍学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 再発膠芽腫におけるベバシズマブの治療成績2015

    • Author(s)
      永野 大輔, 香川 尚己、福永 貴典, 福屋 章悟, 高野 浩司, 平山 龍一, 有田 英之,吉峰 俊樹
    • Organizer
      第33回日本脳腫瘍学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 悪性神経膠腫に対するテモゾロミド併用のWT1ペプチド免疫療法とimmuno RANO2015

    • Author(s)
      橋本直哉、坪井昭博、香川尚己、有田英之、尾路祐介、岡芳弘、吉峰俊樹、杉山治夫
    • Organizer
      第18回WT1ペプチド癌免疫療法研究
    • Place of Presentation
      大阪大学医学部(大阪府吹田市)
    • Year and Date
      2015-03-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 悪性神経膠腫を対象としたWT1キラーペプチドとWT1ヘルパーペプチドを併用したペプチド免疫療法2015

    • Author(s)
      坪井昭博、橋本 直哉、香川尚己、西田 純幸,森本 創世子、藤木 文博、中島 博子、吉峰俊樹、岡 芳弘、杉山治夫
    • Organizer
      第18回WT1ペプチド癌免疫療法研究会
    • Place of Presentation
      大阪大学医学部(大阪府吹田市)
    • Year and Date
      2015-03-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Safe skull fixation using both vacuum patient holding mattress and rigid pin clamp permitting neuronavigation surgery in infants2015

    • Author(s)
      Naoki Kagawa,Amami Kato, Haruhiko Kishima, Naoya Hashimoto, Ryuichi Hirayama, Yasuyoshi Chiba, Satoru Oshino, Toshiki Yoshimine
    • Organizer
      1st Congress of Asian-Australasian Society for Pediatric Neurosurgery and Inaugural Meeting
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-03-20 – 2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 膠芽腫手術におけるナビゲーションと5-ALAの摘出率への寄与について2015

    • Author(s)
      橋本直哉、永野大輔、福屋章悟、高野浩司、平山龍一、有田英之、香川尚己、吉峰俊樹
    • Organizer
      第38回日本脳神経CI学会
    • Place of Presentation
      ウインクあいち(愛知県名古屋市)
    • Year and Date
      2015-02-15
    • Related Report
      2014 Research-status Report
  • [Presentation] 再発髄芽腫に対する治療における分子亜型分類の役割2014

    • Author(s)
      香川 尚己, 平山 龍一, 木嶋 教行, 千葉 泰良, 木下 学, 高野 浩司,永野 大輔, 福屋 章悟, 有田 英之, 山本 福子, 金村 米博, 橋井 佳子, 橋本直哉、原 純一, 吉峰 俊樹
    • Organizer
      第32回日本脳腫瘍学会学術集会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(千葉県浦安市)
    • Year and Date
      2014-12-01
    • Related Report
      2014 Research-status Report
  • [Presentation] FDG / Methionine PET の非造影神経膠腫に対するグレード診断能と予後予測能2014

    • Author(s)
      高野浩司、木下 学、福屋章悟、永野大輔、平山龍一、有田英之、沖田典子、千葉泰良、香川尚己、埜中正博、畑澤 順、橋本直哉、吉峰俊樹
    • Organizer
      第32回日本脳腫瘍学会学術集会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(千葉県浦安市)
    • Year and Date
      2014-12-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 標準脳座標系を用いた髄膜腫の好発部位の可視化2014

    • Author(s)
      平山龍一、木下学、高野浩司、永野大輔、福屋章悟、有田英之、香川尚己、橋本直哉、吉峰俊樹
    • Organizer
      第32回日本脳腫瘍学会学術集会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(千葉県浦安市)
    • Year and Date
      2014-12-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 頭蓋内胚細胞腫における放射線化学療法前の体積変化2014

    • Author(s)
      香川尚己、平山龍一、藤本康倫、千葉泰良、木下学、高野浩司、永野大輔、福屋章悟、有田英之、山本福子、橋本直哉、橋井佳子、原純一、吉峰俊樹
    • Organizer
      第32回日本脳腫瘍学会学術集会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(千葉県浦安市)
    • Year and Date
      2014-11-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 悪性グリオーマに対するWT1 CTL ペプチドとWT1 ヘルパーペプチドを併用した免疫療法2014

    • Author(s)
      橋本直哉, 坪井昭博, 香川尚己, 福屋章悟, 永野大輔, 高野浩司, 平山龍一, 有田英之, 千葉泰良, 木下学, 森本創世子, 岡芳弘, 尾路祐介, 杉山治夫, 吉峰俊樹.
    • Organizer
      第32回日本脳腫瘍学会学術集会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(千葉県浦安市)
    • Year and Date
      2014-11-30
    • Related Report
      2014 Research-status Report
  • [Presentation] テモゾロミドによる潜在性結核感染の再活性化:症例報告と対策2014

    • Author(s)
      藤本康倫, 丸草英司, 香川尚己, 千葉泰良, 橋本直哉, 若山暁, 吉峰俊樹.
    • Organizer
      第32回日本脳腫瘍学会学術集会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(千葉県浦安市)
    • Year and Date
      2014-11-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Comparison of DTI and 11C-methionine PET focusing on their predictive values of tumor cell density in gliomas2014

    • Author(s)
      Manabu Kinoshita, Hideyuki Arita, Naoki Kagawa, Yoshiyuki Watanabe, Jun Hatazawa2, Naoya Hashimoto, Toshiki Yoshimine
    • Organizer
      19th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
    • Place of Presentation
      Miami, USA
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] TUMOR VOLUME OF PRIMARY INTRACRANIAL GERMINOMAS IS CHANGING DYNAMICALLY BEFORE CHEMORADIOTHERAPY2014

    • Author(s)
      Naoki Kagawa, Ryuichi Hirayama, Yasunori Fujimoto, Yasuyoshi Chiba, Manabu Kinoshita, Koji Takano, Daisuke Eino, Shogo Fukuya, Fukuko Yamamoto, Katsuhiko Nakanishi, Naoya Hashimoto, Yoshiko Hashii, Jyunichi Hara and Toshiki Yoshimine
    • Organizer
      SIOP 2014 - 46th Congress of the International Society of Paediatric Oncology
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2014-10-22 – 2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] CLINICAL OUTCOME BY REDUSED-DOSE IRRADIATION PLUS ADJUVANT CHEMOTHERAPY AND PROGNOSIS AFTER RECURRENCE IN MOLECULAR SUBGROUPING OF MEDULLOBLASTOMAS2014

    • Author(s)
      Naoki Kagawa, Ryuichi Hirayama, Noriyuki Kijima, Yasuyoshi Chiba, Manabu Kinoshita, Koji Takano, Daisuke Eino, Shogo Fukuya, Fukuko Yamamoto, Katsuhiko Nakanishi, Yoshiko Hashii, Naoya Hashimoto, Jyunichi Hara, Michael D Taylor and Toshiki Yoshimine
    • Organizer
      SIOP 2014 - 46th Congress of the International Society of Paediatric Oncology
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2014-10-22 – 2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 悪性神経膠腫標準治療のための「標準画像」の探索〜定位サンプリングによる拡散テンソル画像とメチオニンPETの比較から〜2014

    • Author(s)
      木下学、有田英之、沖田典子、香川尚己、貴島晴彦、渡邊嘉之、畑澤順、橋本直哉、吉峰俊樹
    • Organizer
      日本脳神経外科学会 第73回学術総会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 髄芽腫の再発予測と治療戦略における分子亜型分類の意義2014

    • Author(s)
      香川 尚己, 平山 龍一, 木嶋 教行, 千葉 泰良, 有田 英之, 木下 学, 高野 浩司,永野 大輔, 福屋 章悟, 山本 福子, 金村 米博, 橋井 佳子, 原 純一, 橋本 直哉,吉峰 俊樹
    • Organizer
      日本脳神経外科学会 第73回学術総会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2014-10-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 標準治療としてのアミノレブリン酸塩酸塩による術中蛍光診断2014

    • Author(s)
      永野大輔、橋本直哉、福屋章悟、高野浩司、平山龍一、有田英之、千葉泰良、木下学、香川尚己、吉峰俊樹
    • Organizer
      日本脳神経外科学会 第73回学術総会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2014-10-09
    • Related Report
      2014 Research-status Report
  • [Presentation] グリオーマのWT1ペプチドワクチン療法;テモゾロミド併用の効果、バイオマーカーと免疫学的応答2014

    • Author(s)
      橋本直哉、香川尚己、千葉泰良、坪井昭博、木下学、岡芳弘、尾路祐介、泉本修一、有田憲生、杉山治夫、吉峰俊樹
    • Organizer
      日本脳神経外科学会 第73回学術総会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2014-10-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 集学的治療法の変化に伴う乳がん脳転移に対する治療と予後に関する後方視的検討2014

    • Author(s)
      平山龍一、香川尚己、高野浩司、永野大輔、福屋章悟、木下学、橋本直哉、吉峰俊樹
    • Organizer
      日本脳神経外科学会 第73回学術総会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2014-10-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Navigation systemとアミノレブリン酸塩酸塩の初発膠芽腫における摘出率への影響2014

    • Author(s)
      永野大輔、橋本直哉、福屋章悟、高野浩司、平山龍一、有田英之、香川尚己、吉峰俊樹
    • Organizer
      第19回日本脳腫瘍の外科学会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 脳腫瘍に対する覚醒下手術の臨床的検討2014

    • Author(s)
      福屋章悟、 橋本 直哉、 平山 龍一、永野 大輔、 高野 浩司、有田 英之、後藤 哲、千葉 泰良、木下 学、香川 尚己、貴島 晴彦、平田 雅之、吉峰 俊樹
    • Organizer
      第12回Awake Surgery
    • Place of Presentation
      砂防会館(東京都千代田区)
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] WT1 peptide vaccination for malignant gliomas as a part of multi-modal therapy2014

    • Author(s)
      Naoya Hashimoto, Akihiro Tuboi, Yasuyoshi Chiba, Ryuichi Hirayama, Koji Takano, Noriyuki Kijima, Yoshihiro Oka, Naoki Kagawa, Shuichi Izumoto, Haruo Sugiyama, Toshiki Yoshimine
    • Organizer
      ICBTRT2014_20th International Conference on Brain Tumor Research and Therapy
    • Place of Presentation
      California, USA
    • Year and Date
      2014-07-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Retrospective analysis of recurrent patterns and clinical outcome by redused-dose irradiation plus adjuvant chemotherapy in molecular subgrouping of medulloblastomas2014

    • Author(s)
      Naoki Kagawa, Ryuichi Hirayama, Noriyuki Kijima, Yasuyoshi Chiba, Manabu Kinoshita, Koji Takano, Daisuke Eino, Shogo Fukuya, Fukuko Yamamoto, Katsuhiko Nakanishi, Yoshiko Hashii, Naoya Hashimoto, Jyunichi Hara, Michael D Taylor and Toshiki Yoshimine
    • Organizer
      ISPNO 2014 - 16th International Symposium on Pediatric Neuro-Oncology
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2014-06-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Dynamical volumetric changes of primary intracranial germinomas before chemoradiotherapy2014

    • Author(s)
      Naoki Kagawa, Ryuichi Hirayama, Yasunori Fujimoto, Yasuyoshi Chiba, Manabu Kinoshita, Koji Takano, Daisuke Eino, Shogo Fukuya, Fukuko Yamamoto, Katsuhiko Nakanishi, Naoya Hashimoto, Yoshiko Hashii, Jyunichi Hara and Toshiki Yoshimine
    • Organizer
      ISPNO 2014 - 16th International Symposium on Pediatric Neuro-Oncology
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2014-06-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 膠芽腫におけるアミノレブリン酸塩酸塩を用いた術中蛍光診断と摘出率2014

    • Author(s)
      永野大輔、橋本直哉、福屋章悟、高野浩司、平山龍一、有田英之、香川尚己、吉峰俊樹
    • Organizer
      第10回日本脳神経外科光線力学学会
    • Place of Presentation
      アクトシティ浜松 コングレスセンター(静岡県浜松市)
    • Year and Date
      2014-06-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 側頭下窩進展を伴う三叉神経鞘腫に対する内視鏡支援下fronttemporal epidural approach2014

    • Author(s)
      香川尚己、中西克彦、平山龍一、永野大輔、福屋章悟、高野浩司、千葉泰良、橋本直哉、吉峰俊樹
    • Organizer
      第26回日本頭蓋底外科学会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2014-06-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 頭蓋内胚細胞腫における治療前の体積変化に関する考察2014

    • Author(s)
      香川尚己、平山龍一、千葉泰良、永野大輔、福屋章悟、高野浩司、橋井佳子、橋本直哉、吉峰俊樹
    • Organizer
      第13回小児脳腫瘍治療研究会
    • Place of Presentation
      霞ヶ関コモンゲートビル西館(東京都千代田区)
    • Year and Date
      2014-06-14
    • Related Report
      2014 Research-status Report
  • [Presentation] サブグループ別に見た髄芽腫の再発形態と治療戦略2014

    • Author(s)
      香川尚己、平山龍一、千葉泰良、木嶋教行、橋井佳子、原純一、橋本直哉、吉峰俊樹
    • Organizer
      第42回日本小児神経外科学会
    • Place of Presentation
      江陽グランドホテル(宮城県仙台市)
    • Year and Date
      2014-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 小児重症頭部外傷における外減圧術後の頭蓋形成術~カスタムメイド人工骨と吸収性プレートを用いた頭蓋形成術の長期フォローアップ2014

    • Author(s)
      香川尚己、橋井佳子、千葉泰良、平山龍一、橋本直哉、坪井昭博、尾路祐介、岡芳弘、杉山治夫、吉峰俊樹
    • Organizer
      第42回日本小児神経外科学会
    • Place of Presentation
      江陽グランドホテル(宮城県仙台市)
    • Year and Date
      2014-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] MRI画像を基にしたvolumetry法による pilocytic astrocytomaの臨床経過観察と治療効果判定の有用性2014

    • Author(s)
      平山龍一、香川尚己、千葉泰良、圓尾知之、橋本直哉、丸野元彦、吉峰俊樹
    • Organizer
      第42回日本小児神経外科学会
    • Place of Presentation
      江陽グランドホテル(宮城県仙台市)
    • Year and Date
      2014-05-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Spontaneous malignant transformationを来した成人pilocytic astrocytomaの2例2014

    • Author(s)
      高野浩司、香川尚己、木嶋教行、平山龍一、千葉泰良、永野大輔、福屋章悟、橋本直哉、池田純一郎、中里洋一、吉峰俊樹
    • Organizer
      第32回日本脳腫瘍病理学会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 透明中隔に発生したRosette-forming glioneuronal tumorの一小児例2014

    • Author(s)
      永野大輔、香川尚己、福屋章悟、高野浩司、平山龍一、千葉泰良、橋本直哉、森井英一、中里洋一、吉峰俊樹
    • Organizer
      第32回日本脳腫瘍病理学会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2014-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] RESPONSEASSESSMENTS IN WT1 PEPTIDE VACCINATION AND LONG TERM RESULTS OF COMOZOLOMIDE THERAPY2014

    • Author(s)
      Naoya Hashimoto,Akihiro Tsuboi,Yasuyoshi Chiba,Yoshihiro Oka,Soyoko Morimoto,Hiroko Nakajima,Sumiyuki Nishida,Naoki Hosen,Naoki Kagawa,Yusuke Oji,Toshiki Yoshimine,Haruo Sugiyama
    • Organizer
      The7th International Conference on WT1 in human neoplasia
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-04-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 急性水頭症を合併した軟膜悪性黒色腫に対して放射線化学療法を行った神経皮膚黒色症の一例2014

    • Author(s)
      永野大輔、香川尚己、福屋章悟、高野浩司、中西克彦、平山龍一、千葉泰良、橋本直哉、沖永剛志、橋井佳子、吉峰俊樹
    • Organizer
      日本脳神経外科学会近畿支部学術集会
    • Place of Presentation
      千里ライフサイエンスセンター (大阪府吹田市)
    • Year and Date
      2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Spontaneous regression of primary intracranial germinomas: clinical outcomes and histopathological findings.2012

    • Author(s)
      Naoki Kagawa, Yasunori Fujimoto, Ryuichi Hirayama, Yasuyoshi Chiba, Manabu Kinoshita, Naoya Hashimoto Motohiko Maruno and Toshiki Yoshimine.
    • Organizer
      15th International Symposium on Pediatric Neuro-Oncology
    • Place of Presentation
      Toronto
    • Related Report
      2012 Research-status Report
  • [Presentation] Correlation of Wilms’ tumor 1(WT1) expression with histopathological diagnosis and prognosis in pediatric brain tumors.2012

    • Author(s)
      Naoki Kagawa, Ryuichi Hirayama, Yasuyoshi Chiba, Noriyuki Kijima, Hideyuki Arita, Manabu Kinoshita, Naoya Hashimoto, Shuichi Izumoto, Motohiko Maruno and Toshiki Yoshimine.
    • Organizer
      15th International Symposium on Pediatric Neuro-Oncology
    • Place of Presentation
      Toronto
    • Related Report
      2012 Research-status Report
  • [Presentation] 遺伝子発現プロファイリングに基づく髄芽腫サブタイプ分類が臨床治療成績に与える影響.2012

    • Author(s)
      香川尚己、平山龍一、千葉泰良、橋本直哉、丸野元彦、吉峰俊樹.
    • Organizer
      第40回日本小児神経外科学会
    • Place of Presentation
      岡山
    • Related Report
      2012 Research-status Report
  • [Presentation] 頭蓋内胚細胞腫に対する内視鏡的腫瘍生検術が治療成績に与える意義.2012

    • Author(s)
      香川尚己、藤本康倫、平山龍一、千葉泰良、橋本直哉、丸野元彦、吉峰俊樹.
    • Organizer
      第40回日本小児神経外科学会
    • Place of Presentation
      岡山
    • Related Report
      2012 Research-status Report
  • [Presentation] 日本の髄芽腫における遺伝子発現プロファイルに基づいたサブタイプ分類の応用と今後の課題.2012

    • Author(s)
      香川尚己、平山龍一、千葉泰良、木嶋教行、山本福子、木下学、橋本直哉、橋井佳子、原純一、丸野元彦、吉峰俊樹.
    • Organizer
      第54回日本小児血液・がん学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Relationship between activated leukocyte cell adhesion molecule and prognosis in malignant glioma2012

    • Author(s)
      Naoki Kagawa, Naoki Hosen, Noriyuki Kijima, Ryuichi Hirayama, Hideyuki Arita, Manabu Kinoshita, Naoya Hashimoto, Yasunori Fujimoto, and Toshiki Yoshimine
    • Organizer
      第30回日本脳腫瘍病理学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Retrospective analysis of relation between clinical outcome and molecular classification of medulloblastomas2012

    • Author(s)
      Naoki Kagawa, Naoki Hosen, Noriyuki Kijima, Ryuichi Hirayama, Hideyuki Arita, Manabu Kinoshita, Naoya Hashimoto, and Toshiki Yoshimine
    • Organizer
      第30回日本脳腫瘍病理学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Expression of activated leukocyte cell adhesion molecule (ALCAM) influences prognosis in malignant glioma2012

    • Author(s)
      Naoki Kagawa, Naoki Hosen, Noriyuki Kijima, Ryuichi Hirayama, Hideyuki Arita, Manabu Kinoshita, Naoya Hashimoto, Yasunori Fujimoto, and Toshiki Yoshimine
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 分子遺伝学的知見に基づいた髄芽腫サブタイプ分類は予後を予測しうるか2012

    • Author(s)
      香川尚己、平山龍一、木嶋教行、千葉泰良、木下学、橋本直哉、橋井佳子、丸野元彦、吉峰俊樹
    • Organizer
      第30回日本脳腫瘍学会学術総会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
  • [Presentation] 髄芽腫における遺伝子発現プロファイルに基づいたサブタイプ分類と臨床治療成績2012

    • Author(s)
      香川尚己、平山龍一、千葉泰良、木嶋教行、山本福子、木下学、橋本直哉、藤本康倫、丸野元彦、吉峰俊樹
    • Organizer
      第71回日本脳神経外科学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] 急速な増大と悪性転化を示した頭蓋内solitary fibrous tumor の一小児例

    • Author(s)
      香川尚己、平山龍一、千葉泰良、木下学、橋本直哉、宮村能子、橋井佳子、森井英一、中里洋一、吉峰俊樹.
    • Organizer
      日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 分子遺伝学的知見に基づいた髄芽腫分類と臨床試験における今後の展望

    • Author(s)
      香川尚己、平山龍一、千葉泰良、木嶋教行、橋本直哉、木下学、高野浩司、橋井佳子、原純一、吉峰俊樹
    • Organizer
      日本小児神経外科学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Research-status Report
  • [Presentation] こども虐待の動向

    • Author(s)
      香川尚己
    • Organizer
      小児医療センターセミナー
    • Place of Presentation
      阪大病院(大阪)
    • Related Report
      2013 Research-status Report
  • [Presentation] 周術期ガイドライン導入と内視鏡的支援手術が小児水頭症における脳室腹腔短絡術の治療成績を改善する

    • Author(s)
      香川尚己、千葉泰良、平山龍一、圓尾知之、木嶋教行、高野浩司、木下学、橋本直哉、吉峰俊樹
    • Organizer
      日本脳神経外科学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] 内視鏡的第三脳室底開窓術の適応と長期治療成績に関する考察

    • Author(s)
      香川尚己、藤本康倫、平山龍一、千葉泰良、圓尾知之、高野浩司、木下学、橋本直哉、貴島晴彦、吉峰俊樹
    • Organizer
      日本神経内視鏡学会
    • Place of Presentation
      甲府富士屋ホテル(甲府)
    • Related Report
      2013 Research-status Report
  • [Presentation] 小児脳神経外科領域における鎮静、党員における現状と問題点

    • Author(s)
      香川尚己、千葉泰良、圓尾知之、平山龍一、和田和子、橋井佳子、下野九里子、高橋りょう子、橋本直哉、貴島晴彦、吉峰俊樹
    • Organizer
      日本こども病院神経外科医会
    • Place of Presentation
      自治医科大(宇都宮)
    • Related Report
      2013 Research-status Report
  • [Presentation] A questionnairaire-based survey for management of children with brain tumors in Japan and opinions about selection and integration of institutions

    • Author(s)
      香川尚己、吉峰俊樹、柳沢隆昭、原純一
    • Organizer
      日本小児血液・がん学会学術集会
    • Place of Presentation
      ヒルトン福岡シーホース(福岡)
    • Related Report
      2013 Research-status Report
  • [Presentation] 神経膠芽腫におけるCD166発現とsubventricular zoneとの関係-再発形式と予後への影響

    • Author(s)
      香川尚己、木嶋教行、保仙直毅、平山龍一、千葉泰良、高野浩司、木下学、中西克彦、永野大輔、福屋章悟、藤本康倫、橋本直哉、吉峰俊樹
    • Organizer
      日本脳腫瘍学会学術集会
    • Place of Presentation
      フェニックスシーガイアリゾート(宮崎)
    • Related Report
      2013 Research-status Report
  • [Presentation] Optico-hypothalamic gliomaの治療効果判定と臨床経過の追跡-MRI volumetryによる継時的観察法の試み‐.

    • Author(s)
      香川尚己、平山龍一、千葉泰良、木嶋教行、木下学、橋本直哉、丸野元彦、吉峰俊樹.
    • Organizer
      第11回日本小児脳腫瘍治療研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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