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compensatory hypertrophy of the infraspinatus muscle in rotator cuff tear rat model

Research Project

Project/Area Number 24592184
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionGunma University

Principal Investigator

TAKAGISHI Kenji  群馬大学, 医学(系)研究科(研究院), 教授 (70154763)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Atsushi  群馬大学, 医学部, 助教 (30400732)
ICHINOSE Tsuyoshi  群馬大学, 医学部付属病院, 助教 (70742550)
Co-Investigator(Renkei-kenkyūsha) KOIBUCHI Noriyuki  群馬大学, 大学院医学系研究科, 教授 (80234681)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords腱板断裂 / 代償性筋肥大 / IGF-1 / Akt / mTOR
Outline of Final Research Achievements

The measurement of the weight change and the expression of muscle hypertrophy-related genes in rotator cuff muscle of rotator cuff tear (RCT) rat model revealed that the expression of muscle hypertrophy-related genes in the remaining muscle increased. Particularly, this phenomenon become significant when the rotator cuff tear extend. Our RCT rat model made by the transection of suprascapular nerve and the supraspinatus and infraspinatus tendon, showed significant hypertrophy and activated muscle hypertrophy-related gene in the remaining teres minor muscle.
Our results support the therapeutic concept which aims regaining rotator cuff function via training of the remaining muscle.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder2014

    • Author(s)
      Ichinose T, Lesmana R, Yamamoto A, Kobayashi T, Shitara H, Shimoyama D, Takatsuru Y, Iwasaki T, Shimokawa N, Takagishi K, Koibuchi N
    • Journal Title

      Physiological Rep

      Volume: 2 Issue: 1 Pages: 1-10

    • DOI

      10.1002/phy2.197

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder2014

    • Author(s)
      Tsuyoshi Ichinose
    • Organizer
      22nd Spring Congress of Korean Shoulder and Elbow Society
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] 棘上筋腱断裂モデルラットにおける棘下筋の代償性肥大2012

    • Author(s)
      一ノ瀬 剛
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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