compensatory hypertrophy of the infraspinatus muscle in rotator cuff tear rat model

• Project/Area Number: 24592184
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Gunma University
• Principal Investigator: TAKAGISHI Kenji 群馬大学, 医学(系)研究科(研究院), 教授 (70154763)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Atsushi 群馬大学, 医学部, 助教 (30400732) ; ICHINOSE Tsuyoshi 群馬大学, 医学部付属病院, 助教 (70742550)
• Co-Investigator(Renkei-kenkyūsha): KOIBUCHI Noriyuki 群馬大学, 大学院医学系研究科, 教授 (80234681)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 腱板断裂 / 代償性筋肥大 / IGF-1 / Akt / mTOR

Outline of Final Research Achievements

The measurement of the weight change and the expression of muscle hypertrophy-related genes in rotator cuff muscle of rotator cuff tear (RCT) rat model revealed that the expression of muscle hypertrophy-related genes in the remaining muscle increased. Particularly, this phenomenon become significant when the rotator cuff tear extend. Our RCT rat model made by the transection of suprascapular nerve and the supraspinatus and infraspinatus tendon, showed significant hypertrophy and activated muscle hypertrophy-related gene in the remaining teres minor muscle.
Our results support the therapeutic concept which aims regaining rotator cuff function via training of the remaining muscle.

Research Products

• [Journal Article] Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder (2014)
  • Author(s): Ichinose T, Lesmana R, Yamamoto A, Kobayashi T, Shitara H, Shimoyama D, Takatsuru Y, Iwasaki T, Shimokawa N, Takagishi K, Koibuchi N
  • Journal Title: Physiol Rep Volume: 2 Pages: 1-10
  • DOI: 10.1002/phy2.197
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder (2014)
  • Author(s): Tsuyoshi Ichinose
  • Organizer: 22nd Spring Congress of Korean Shoulder and Elbow Society
  • Place of Presentation: Seoul, Korea
• [Presentation] 棘上筋腱断裂モデルラットにおける棘下筋の代償性肥大 (2012)
  • Author(s): 一ノ瀬 剛
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 愛知県名古屋市