Functional analysis of RAMP and CXCL14 in skeletal muscle regeneration.

• Project/Area Number: 24592202
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kumamoto University
• Principal Investigator: Nakayama Yuki 熊本大学, 大学院先端科学研究部(理), 准教授 (30332381)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ケモカイン / 骨格筋 / 再生 / 筋分化 / マウス / 筋再生 / マクロファージ / 分泌タンパク質 / 分泌性タンパク質

Outline of Final Research Achievements

The aim of this study is to investigate the physiological function of RAMP and CXCL14 whose expression is enhanced in skeletal muscles after injury. Regarding RAMP, co-localization of RMAP and LYVE1 protein does not occur in skeletal muscle. It has been reported that CXCL14 has a function of inhibiting the binding of CXCL12 to CXCR4, but it was revealed that such effect was not seen with C2C12. Furthermore, it was revealed that CXCL14 promotes muscle regeneration during mouse skeletal muscle regeneration.

Research Products

• [Presentation] 筋再生過程におけるTβ4の機能解析 (2015)
  • Author(s): 永江 亜美、中山 由紀
  • Organizer: 第38回日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2015-12-01
• [Presentation] 筋再生過程におけるCXCL14の機能解析 (2015)
  • Author(s): 田辺 舞、中山 由紀
  • Organizer: 第38回日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2015-12-01
• [Presentation] イモリ筋再生のメカニズム (2014)
  • Author(s): 下鶴 健太郎 中山由紀
  • Organizer: 発生生物学会
  • Place of Presentation: 名古屋 ウインクあいち
  • Year and Date: 2014-05-27 – 2014-05-30
• [Presentation] 筋分化過程におけるBRINP３の機能解析 (2013)
  • Author(s): 田口 文、中山 由紀
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Analysis of CXCL14 and its receptors in muscle differentiation (2012)
  • Author(s): Daiki Shuto, Yuki Nakayama
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場
• [Presentation] The roles of CXCL14 and its receptors in skeletal muscle differentiation. (2012)
  • Author(s): Daiki Shuto, Kosuke Tanegashima, Kenji Suzuki, Takahiko Hara, Shinichi Abe, Kou Eto, Yuki Nakayama
  • Organizer: 第45回発生生物学会年会
  • Place of Presentation: 神戸国際会議場