| Project/Area Number |
24592252
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Kan 山形大学, 医学部, 准教授 (00444034)
TAKAKUBO Yuya 山形大学, 医学部, 講師 (80431461)
高窪 祐弥 山形大学, 医学部, 講師 (80431641)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 人工股関節の弛み / 自然免疫 / TLR / NLR / Aseptic loosening / Osteolysis / Total hip arthropasty / 感染性人工関節 / Toll-like receptor / NOD-like receptor / osteolysis / Toll様受容体 / NOD様受容体 / 人工関節 / 非感染性骨溶解 |
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| Outline of Final Research Achievements |
We have demonstrated that TLR1, TLR2, TLR6 and NLRP3 expressions on macrophages, fibroblsts and neutrophils in the periprosthetic tissue from infected and aseptic loose hip joints. mRNA expression of TLR2, NLRP3, TNF-α and IL-1β on phagocytes stimulating by LTA-coating titanium particles were ehnanced, whereas, reinforced secretion of IL-1β was not detected in spite of marked release of TNF-α.
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