Analyses of innate immune sensors, TLR and NLR, in periprosthetic infection.
Project/Area Number |
24592252
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Yamagata University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SASAKI Kan 山形大学, 医学部, 准教授 (00444034)
TAKAKUBO Yuya 山形大学, 医学部, 講師 (80431461)
高窪 祐弥 山形大学, 医学部, 講師 (80431641)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 人工股関節の弛み / 自然免疫 / TLR / NLR / Aseptic loosening / Osteolysis / Total hip arthropasty / 感染性人工関節 / Toll-like receptor / NOD-like receptor / osteolysis / Toll様受容体 / NOD様受容体 / 人工関節 / 非感染性骨溶解 |
Outline of Final Research Achievements |
We have demonstrated that TLR1, TLR2, TLR6 and NLRP3 expressions on macrophages, fibroblsts and neutrophils in the periprosthetic tissue from infected and aseptic loose hip joints. mRNA expression of TLR2, NLRP3, TNF-α and IL-1β on phagocytes stimulating by LTA-coating titanium particles were ehnanced, whereas, reinforced secretion of IL-1β was not detected in spite of marked release of TNF-α.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Macrophages-Key cells in the response to wear debris from joint replacements2013
Author(s)
Nich C, Takakubo Y, Pajarinen J, Ainola M, Salem A, Sillat T, Rao AJ, Raska M, Tamaki Y, Takagi M, Konttinen YT, Goodman SB, Gallo J
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Journal Title
J Biomed Mater Res A
Volume: 101
Pages: 3033-3045
Related Report
Peer Reviewed
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[Presentation] Immunohistochemical localization and cellular reaction of TLR2 and NLRP3 cascades in aseptic loosening of totally replaced hip joints.2015
Author(s)
Naganuma Y, Hirayama T, Ooki H, Liu X, Yang S, Tamaki Y, Takakubo Y, Sasaki K, Takagi M
Organizer
Orthopaedic Research Society annual meeting
Place of Presentation
MGM Grand Hotel, Las Vegas, Nevada USA
Year and Date
2015-03-28 – 2015-03-31
Related Report
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[Presentation] 異物肉芽腫反応とリウマチ性関節炎におけるマクロファージの役割.2014
Author(s)
玉木康信, Jukka Pajarinen, 高窪祐弥, 梁秀蘭, 長沼靖, 平山朋幸, 大木弘治, 佐々木幹, 川路博之, 石井政次, Hekki Valleala, Yrjo T. Konttinen, Stuart B. Goodman, 高木理彰
Organizer
第29回日本整形外科学会基礎学術集会
Place of Presentation
城山観光ホテル, 鹿児島
Year and Date
2014-10-09 – 2014-10-10
Related Report
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[Presentation] Total Joint Arthroplasties for Rheumatoid Arthritis in Era of Biologics.2014
Author(s)
Takakubo Y, Sasaki K, Narita A, Oki H, Hirayama T, Suzuki A, TamakiY, Togashi E, Kawaji H, Fukushima S, Ishii M, Takagi M
Organizer
ISTA 2014 Kyoto Scientific
Place of Presentation
Hotel Okura Kyoto, Kyoto, Japan
Year and Date
2014-09-24 – 2014-09-27
Related Report
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[Presentation] Analyses on immunohistochemical localization of TLR2 and NLRP3 in aseptic periprosthetic tissues around loose hip joints and their response to foreign body particles.2014
Author(s)
Naganuma Y, Hirayama T, Tamaki Y, Takakubo Y, Oki H, Yang S, Sasaki K, Kawaji H, Ishii M, Takagi M
Organizer
ISTA 2014 Kyoto Scientific
Place of Presentation
Hotel Okura Kyoto, Kyoto, Japan
Year and Date
2014-09-24 – 2014-09-27
Related Report
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[Presentation] Is podoplanin a new candidate of inflammatory markers for rheumatoid arthritis?2014
Author(s)
Takakubo Y, Ohki H, Yang S, Sasaki A, Sasaki K, Hirayama T,Tamaki Y,Naganuma Y, Yukinari Kato, Takagi M
Organizer
European League Against Rheumatism 2014
Place of Presentation
Palais des Congres, Paris, France
Year and Date
2014-06-11 – 2014-06-14
Related Report
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[Presentation] The concentration of serum interleukin-6 before biologic treatment are related to clinical response in the patients of rheumatoid arthritis.2014
Author(s)
Takakubo Y, Ohki H, Yang S, Sasaki A, Sasaki K, Hirayama T,Tamaki Y,Naganuma Y,Orui H, Takagi M
Organizer
European League Against Rheumatism 2014
Place of Presentation
Palais des Congres, Paris, France
Year and Date
2014-06-11 – 2014-06-14
Related Report
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[Presentation] 人工股関節の現状と課題.2014
Author(s)
高木理彰
Organizer
第122回中部日本整形外科災害外科学会学術集会
Place of Presentation
岡山コンベンションセンター, 岡山
Year and Date
2014-04-11 – 2014-04-12
Related Report
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[Presentation] Periprosthetic osteolysis around total hip implantspast, present and future2013
Author(s)
Takagi M, Sasaki K, Takakubo Y, Tamaki Y, Hirayama T, Naganuma Y, Kawaji H, Ishii M
Organizer
The 57th Annual Fall Congress,Korean Orthopaedic Association
Place of Presentation
Grand Hilton Hotel, Seoul, Korea
Related Report
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