Roles of membrane transport protein Rab38 on bone metabolism.

Research Project

Project/Area Number	24592255
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Orthopaedic surgery
Research Institution	The University of Tokyo
Principal Investigator	YASUI Tetsuro 東京大学, 医学部附属病院, 講師 (30583108)
Co-Investigator(Kenkyū-buntansha)	OSHIMA Yasushi 東京大学, 医学部附属病院, 講師 (50570016) KADONO Yuho 東京大学, 医学部附属病院, 講師 (70401065)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	破骨細胞 / Rab38 / 破骨細胞分化
Outline of Final Research Achievements	We picked up Rab38 gene as an osteoclast differentiating factor by analyzing changes of histone modifications during murine cell differentiation from bone marrow cell to osteoclast. Osteoclast differentiation was suppressed by Rab38 knock down with siRNA in vitro, but phenotype change was not observed in Rab38 knock out mouse in vitro. We concluded that Rab38 does not affect osteoclast differentiation by itself though it may concern in some form or other.