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Roles of membrane transport protein Rab38 on bone metabolism.

Research Project

Project/Area Number 24592255
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

YASUI Tetsuro  東京大学, 医学部附属病院, 講師 (30583108)

Co-Investigator(Kenkyū-buntansha) OSHIMA Yasushi  東京大学, 医学部附属病院, 講師 (50570016)
KADONO Yuho  東京大学, 医学部附属病院, 講師 (70401065)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords破骨細胞 / Rab38 / 破骨細胞分化
Outline of Final Research Achievements

We picked up Rab38 gene as an osteoclast differentiating factor by analyzing changes of histone modifications during murine cell differentiation from bone marrow cell to osteoclast. Osteoclast differentiation was suppressed by Rab38 knock down with siRNA in vitro, but phenotype change was not observed in Rab38 knock out mouse in vitro. We concluded that Rab38 does not affect osteoclast differentiation by itself though it may concern in some form or other.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2014

All Presentation (2 results)

  • [Presentation] Chromatin remodeling by NFATc1 requires STAT3 in osteoclastogenesis2014

    • Author(s)
      伊沢直広, 野村征太郎, 宮本健史, 油谷浩幸, 田中栄
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Genome-wide comprehensive analysis demonstrates that PU.1 cooperates with NFATc1 in osteoclastogenesis2014

    • Author(s)
      伊沢直広, 油谷浩幸, 田中栄
    • Organizer
      5th International Conference on Osteoimmunology
    • Place of Presentation
      Kos, Greece
    • Year and Date
      2014-06-17
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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