| Project/Area Number |
24592338
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka University |
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Principal Investigator |
FUJINO Yuji 大阪大学, 医学(系)研究科(研究院), 教授 (50252672)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Noriyuki 大阪大学, 医学部附属病院, 助教 (60379162)
後藤 幸子 大阪大学, 医学(系)研究科(研究院), 助教 (20276710)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 樹状細胞 / プロポフォール / 脂質懸濁液 / Th1/Th2 / 接触過敏症 / 鎮静薬 / Th1 / 心筋炎 / Th1型免疫応答 / 自己免疫 / インターフェロンγ |
|---|
| Outline of Final Research Achievements |
Dendritic cells (DCs), as antigen-presenting cells, play a key role in the induction and regulation of adaptive immune response. Propofol is reported to have immunomodulatory properties that affect immune cells. However, the effect of propofol on DCs has not been characterized. We examined the immunomodulatory properties of propofol on DC-mediated immune response. Propofol promoted the functional maturation of murine DCs and augmented DC induction of T helper 1 immunity in the whole mouse. In addition, it appears that the immunostimulatory effect of propofol is attributed to the component of lipid emulsion rather than anesthetic propofol itself.
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