| Project/Area Number |
24592347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kagoshima University |
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Principal Investigator |
OWAKI TETSUHIRO 鹿児島大学, 医歯(薬)学総合研究科, 教授 (50322318)
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| Co-Investigator(Kenkyū-buntansha) |
NEROME Yasuhito 鹿児島大学, 大学院医歯学総合研究科, 准教授 (00457657)
OKUMURA Hiroshi 鹿児島大学, 大学院医歯学総合研究科, 講師 (10398282)
UENO Shinichi 鹿児島大学, 大学院医歯学総合研究科, 特任教授 (40322317)
NATSUGOE Shoji 鹿児島大学, 大学院医歯学総合研究科, 教授 (70237577)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 手術侵襲 / 抗酸化力 / 酸化ストレス / d-ROM / BAP / 食道癌 / 定量化 / 活性酸素 / 外科 |
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| Outline of Final Research Achievements |
We examined oxidative stress value (d-ROMs: Reactive Oxygen Metabolites derived compounds), quantification of the operative invasion by the antioxidant titer (BAP: Biological Antioxidant Potential).
The d-ROMs/BAP ratio was high just after the operation of the esophagectomy, laparotomy gastorectomy, pancreatoduodenectomy and 2 central segmentectomy of the liver which were one of the most invasive surgery. In the esophagectomy, the d-ROM level significantly decreased just after an operation and recovered on day one after an operation, and recoverd to a previous value on the third day .BAP of eyes, d-ROMs significantly correlated with an operative time and bleeding just after an operation on postoperative 1/3/7 day, and it was confirmed that these showed metrics of the operative invasion.
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