The antinociceptive effect of sevoflurane

• Project/Area Number: 24592359
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Tokai University
• Principal Investigator: KANAZAWA Masahiro 東海大学, 医学部, 准教授 (60276847)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Masanobu 東海大学, 医学部, 准教授 (90276791)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: セボフルラン / 鎮痛効果 / 鎮痛 / 脊髄 / オピオイド / Dセリン

Outline of Final Research Achievements

Intrathecal administration of sevoflurane induced dose-dependently （0.2-10μl）antinociceptive effects using tail flick test (ED50: 0.7 microlitter). The contents of sevoflurane was 0.9 mM in the cerebral spinal fluids of rats under sevoflurane anesthesia (1 MAC). The artificial cerebral spinal fluids containing sevoflurane (2.6 mM) induced antinociceptive effects, but not motor dysfunction.

Research Products

• [Journal Article] Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain (2014)
  • Author(s): Ito M, Yoshikawa M, Ito K, Matsuda M, Jin X.L., Takahashi S, Kobayashi H, Suzuki T
  • Journal Title: J. Anesthesia Volume: 28 Pages: 228-234
  • Peer Reviewed
• [Journal Article] Increase in antinociceptive effect of [Leu5]enkephalin after intrathecal administration of mixture of three peptidase inhibitors (2014)
  • Author(s): Miura, M, Yoshikawa M, Watanabe M, Takahashi S, Ajimi J, Ito K, Ito M, Kawaguchi M, Kobayashi H, Suzuki T.
  • Journal Title: Tokai J Exp Clin Med Volume: 38 Pages: 62-70
  • Peer Reviewed
• [Journal Article] Methamphetamine-withdrawal stress activates PACAP-DBI pathway in rat salivary gland, resulting in inhibition of salivary secretion (2014)
  • Author(s): Okubo M, Yoshikawa M, Shinomiya T, Kawaguchi M
  • Journal Title: Tokai J Exp Clin Med Volume: 38 Pages: 55-61
  • Peer Reviewed