The antinociceptive effect of sevoflurane

Research Project

Project/Area Number	24592359
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Tokai University
Principal Investigator	KANAZAWA Masahiro 東海大学, 医学部, 准教授 (60276847)
Co-Investigator(Kenkyū-buntansha)	YOSHIKAWA Masanobu 東海大学, 医学部, 准教授 (90276791)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	セボフルラン / 鎮痛効果 / 鎮痛 / 脊髄 / オピオイド / Dセリン
Outline of Final Research Achievements	Intrathecal administration of sevoflurane induced dose-dependently （0.2-10μl）antinociceptive effects using tail flick test (ED50: 0.7 microlitter). The contents of sevoflurane was 0.9 mM in the cerebral spinal fluids of rats under sevoflurane anesthesia (1 MAC). The artificial cerebral spinal fluids containing sevoflurane (2.6 mM) induced antinociceptive effects, but not motor dysfunction.

Report

(4 results)