Mechanism of airway hyperresponsiveness after lung transplantation
| Project/Area Number |
24592366
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
CHIBA Yoshihiko 星薬科大学, 薬学部, 准教授 (00287848)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肺移植 / 肺 / 虚血再潅流傷害 / マイクロRNA / 麻酔薬 |
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| Outline of Final Research Achievements |
It has been reported that an airway hyperresponsiveness (AHR) was observed in the non-asthmatic recipients who received lung transplantation. The mechanism of AHR after lung transplantation is unclear, and various factors seem to be involved in. Sugammadex was expected to be useful for anesthetic management of patients with bronchial asthma. However, several cases of bronchospasm after administration of sugammadex were reported. We examined the effects of rocuronium-sugammadex clathrate on rat airway smooth muscle (ASM) contraction, and the clathrate had no effect on the function of ASM.
Next, lung ischemia-reperfusion (I-R) injury is the main problem in management of patients after lung transplantation surgery. We examined whether small G-protein RhoA and CPI-17 are involved in lung I-R injury in rats, because they have been shown to have a key role in airway hyper responsiveness. In this study, up-regulations of RhoA and CPI-17were shown in rat lung ischemia-reperfusion injury.
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Report
(4 results)
Research Products
(31 results)
