Identification of molecules involved in progression of prostate cancer and construction of risk prediction model using SNP array

• Project/Area Number: 24592373
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Akita University
• Principal Investigator: TSUCHIYA Norihiko 秋田大学, 医学(系)研究科(研究院), 准教授 (70282176)
• Co-Investigator(Kenkyū-buntansha): HABUCHI Tomonori 秋田大学, 大学院医学系研究科, 教授 (00293861) ; NARITA Shintaro 秋田大学, 医学部, 講師 (40396552)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 前立腺癌 / 遺伝子多型 / CYP19 / 骨転移 / 予後 / SNPアレイ

Outline of Final Research Achievements

In this study, we evaluated a biological functional of the CYP19 polymorphisms. The ratio of serum estrone/ androstenedione was significantly associated with the CYP19 polymorphisms and the polymorphisms altered the promoter activity of the CYP19 gene. Additionally, the cancer-specific survival of metastatic prostate cancer patients was significantly associated with the CYP19 polymorphisms. Those finding suggest that the CYP19 polymorphisms influence the risk and outcome of prostate cancer through the alteration in sex hormone milieu.

Research Products

• [Journal Article] Effects of functional genetic polymorphisms in the CYP19A1 gene on prostate cancer risk and survival (2015)
  • Author(s): Kanda S, Tsuchiya N, Narita S, et al.
  • Journal Title: Int J Cancer Volume: 136 Issue: 1 Pages: 74-82
  • DOI: 10.1002/ijc.28952
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 泌尿器がんにおける新規分子マーカーとしての遺伝子多型の臨床応用 (2014)
  • Author(s): 土谷順彦
  • Journal Title: 秋田医学 Volume: 41 Pages: 5-15
  • NAID: 110009839546
• [Journal Article] Distinct cancer-specific survival in metastatic prostate cancer patients classified by a panel of single nucleotide polymorphisms of cancer-associated genes. (2013)
  • Author(s): Tsuchiya N, Matsui S, Narita S, Kamba T, Mitsuzuka K, Hatakeyama S, Horikawa Y, Inoue T, Saito S, Ohyama C, Arai Y, Ogawa O, Habuchi T.
  • Journal Title: Genes Cancer. Volume: 4 Issue: 1-2 Pages: 54-60
  • DOI: 10.1177/1947601913481354
  • Peer Reviewed
• [Journal Article] Insulin-like growth factor-1 genotypes and haplotypes influence the survival of prostate cancer patients with bone metastasis at initial diagnosis (2013)
  • Author(s): Tsuchiya N
  • Journal Title: BMC Cancer Volume: 13 Issue: 1 Pages: 150-150
  • DOI: 10.1186/1471-2407-13-150
  • Peer Reviewed
• [Presentation] The SNP panel of cancer-associate genes in predicting survival of metastatic prostate cancer (2013)
  • Author(s): Tsuchiya, N.
  • Organizer: Asan-Michinoku Urology Sympodium
  • Place of Presentation: Seoul, South Korea
  • Invited
• [Presentation] Functional genetic polymorphisms in CYP19 decrease the risk of prostate cancer development and alter the response to androgen deprivation therapy (2012)
  • Author(s): Sohei Kanda, Norihiko Tsuchiya, Mingguo Huang, Syuji Chiba, Kiyofumi Satoyoshi, et al.
  • Organizer: The 107th annual meeting of the American Urological Association
  • Place of Presentation: Altanta
• [Presentation] Functional genetic polymorphisms in CYP19 decrease the risk of prostate cancer development and alter the response to androgen deprivation therapy (2012)
  • Author(s): Sohei Kanda, Norihiko Tsuchiya, Mingguo Huang, Syuji Chiba, Kiyofumi Satoyoshi, et al.
  • Organizer: The 32nd congress of the societe international d’urologie
  • Place of Presentation: Fukuoka
• [Presentation] 前立腺癌におけるCYP19遺伝子多型の臨床的意義 (2012)
  • Author(s): 神田壮平，土谷順彦，黄 民国，千葉修治，里吉清文，米田真也，沼倉一幸，小原 崇，井上高光，成田伸太郎，堀川洋平，佐藤 滋，羽渕友則
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 横浜